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| H | Puebla FC | - | CF América | 1:6 (1:2) | ||
| R | CF América | - | Puebla FC | 5:1 (2:1) | ||
| H: 13.10.2022 02:06 | R: 16.10.2022 03:06 | Sieger: CF América | ||||
| H | Cruz Azul | - | CF Monterrey | 0:0 (0:0) | ||
| R | CF Monterrey | - | Cruz Azul | 3:0 (1:0) | ||
| H: 13.10.2022 04:06 | R: 16.10.2022 01:06 | Sieger: CF Monterrey | ||||
| H | Deportivo Toluca | - | Santos Laguna | 4:3 (2:2) | ||
| R | Santos Laguna | - | Deportivo Toluca | 1:2 (0:0) | ||
| H: 14.10.2022 02:06 | R: 17.10.2022 02:06 | Sieger: Deportivo Toluca | ||||
| H | UANL Tigres | - | CF Pachuca | 1:0 (0:0) | ||
| R | CF Pachuca | - | UANL Tigres | 2:1 (1:0) | ||
| H: 14.10.2022 04:06 | R: 17.10.2022 04:06 | Sieger: UANL Tigres | ||||
