 |
 |
|
|
| 26.03.2022 | 19:30 | CF Monterrey | - | Santos Laguna | 1:2 (0:1) | |
| 30.03.2022 | 19:00 | Gallos Blancos | - | UANL Tigres | 1:1 (1:1) | |
| 07.04.2022 | 18:30 | Atlas Guadalajara | - | Club Necaxa | 1:3 (1:1) | |
| 08.04.2022 | 19:15 | Puebla FC | - | Pumas UNAM | 2:4 (2:1) | |
| 20:30 | Mazatlán FC | - | Cruz Azul | 1:2 (1:1) | ||
| 09.04.2022 | 19:00 | CF América | - | FC Juárez | 3:0 (0:0) | |
| 19:30 | Atlético San Luis | - | Club León | 2:2 (1:1) | ||
| 19:30 | Deportivo Toluca | - | Deportivo Guadalajara | 3:3 (0:2) | ||
| 11.04.2022 | 16:00 | CF Pachuca | - | Club Tijuana | 1:2 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 13 | 9 | 3 | 1 | 29:13 | 16 | 40 |
| 2 |
|
Atlas Guadalajara | 13 | 7 | 5 | 1 | 20:11 | 9 | 37 |
| 3 |
|
Club León | 13 | 8 | 3 | 2 | 19:12 | 7 | 34 |
| 4 |
|
Deportivo Guadalajara | 13 | 7 | 4 | 2 | 28:15 | 13 | 33 |
| 5 |
|
Santos Laguna | 13 | 6 | 5 | 2 | 26:14 | 12 | 32 |
| 6 |
|
Club Tijuana | 13 | 6 | 3 | 4 | 22:22 | 0 | 32 |
| 7 |
|
Pumas UNAM | 13 | 6 | 3 | 4 | 18:15 | 3 | 28 |
| 8 |
|
CF Monterrey | 13 | 5 | 2 | 6 | 23:27 | -4 | 28 |
| 9 |
|
Cruz Azul | 13 | 5 | 2 | 6 | 15:17 | -2 | 26 |
| 10 |
|
Deportivo Toluca | 13 | 4 | 5 | 4 | 19:17 | 2 | 25 |
| 11 |
|
CF Pachuca | 13 | 6 | 0 | 7 | 22:21 | 1 | 25 |
| 12 |
|
UANL Tigres | 13 | 4 | 3 | 6 | 16:26 | -10 | 24 |
| 13 |
|
Atlético San Luis | 13 | 5 | 2 | 6 | 19:19 | 0 | 23 |
| 14 |
|
Club Necaxa | 13 | 4 | 2 | 7 | 18:22 | -4 | 21 |
| 15 |
|
Mazatlán FC | 13 | 2 | 4 | 7 | 13:26 | -13 | 20 |
| 16 |
|
Gallos Blancos | 13 | 3 | 1 | 9 | 9:18 | -9 | 17 |
| 17 |
|
Puebla FC | 13 | 1 | 5 | 7 | 9:20 | -11 | 17 |
| 18 |
|
FC Juárez | 13 | 1 | 4 | 8 | 14:24 | -10 | 14 |
| Playoffs |
