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| H | Santos Laguna | - | Atlas Guadalajara | 1:2 (1:1) | ||
| R | Atlas Guadalajara | - | Santos Laguna | 3:3 (2:0) | ||
| H: 05.10.2022 16:00 | R: 08.10.2022 18:30 | Sieger: Atlas Guadalajara | ||||
| H | CF América | - | Deportivo Guadalajara | 2:1 (2:0) | ||
| R | Deportivo Guadalajara | - | CF América | 1:2 (1:1) | ||
| H: 05.10.2022 18:00 | R: 08.10.2022 17:00 | Sieger: CF América | ||||
| H | Pumas UNAM | - | Deportivo Toluca | 0:1 (0:0) | ||
| R | Deportivo Toluca | - | Pumas UNAM | 2:0 (0:0) | ||
| H: 06.10.2022 17:00 | R: 09.10.2022 18:30 | Sieger: Deportivo Toluca | ||||
| H | Club Tijuana | - | CF Pachuca | 2:1 (2:1) | ||
| R | CF Pachuca | - | Club Tijuana | 2:1 (1:0) | ||
| H: 07.10.2022 06:00 | R: 09.10.2022 16:00 | |||||
