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| H | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| R | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| H: 02.12.2021 18:00 | R: 05.12.2021 18:00 | Sieger: Santos Laguna | ||||
|
|
|
| H | Cruz Azul | - | Santos Laguna | 2:1 (0:0) | ||
| R | Santos Laguna | - | Cruz Azul | 3:0 (2:0) | ||
| H: 02.12.2021 18:00 | R: 05.12.2021 18:00 | Sieger: Santos Laguna | ||||
