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| 26.02.2022 | 14:00 | Makedonija GP | - | FK Bregalnica Štip | 2:1 (2:0) | |
| 27.02.2022 | 14:00 | FK Borec | - | FC Struga | 0:1 (0:0) | |
| 14:00 | KF Shkupi | - | GFK Tikvesh | 3:2 (1:0) | ||
| 14:00 | FK Skopje | - | FK Rabotnički | 0:1 (0:1) | ||
| 14:00 | KF Shkëndija 79 | - | Akademija Pandev | 0:0 (0:0) | ||
| 28.02.2022 | 14:00 | FK Pelister | - | FK Renova | 1:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 21 | 16 | 3 | 2 | 49:14 | 35 | 51 |
| 2 |
|
KF Shkëndija 79 | 21 | 11 | 8 | 2 | 34:15 | 19 | 41 |
| 3 |
|
Akademija Pandev | 21 | 11 | 6 | 4 | 34:20 | 14 | 39 |
| 4 |
|
Makedonija GP | 21 | 11 | 3 | 7 | 31:32 | -1 | 36 |
| 5 |
|
FK Renova | 21 | 8 | 7 | 6 | 28:19 | 9 | 31 |
| 6 |
|
FK Bregalnica Štip | 21 | 8 | 6 | 7 | 30:30 | 0 | 30 |
| 7 |
|
FC Struga | 21 | 7 | 9 | 5 | 17:18 | -1 | 30 |
| 8 |
|
FK Rabotnički | 21 | 8 | 4 | 9 | 16:20 | -4 | 28 |
| 9 |
|
FK Skopje | 21 | 5 | 6 | 10 | 14:29 | -15 | 21 |
| 10 |
|
GFK Tikvesh | 21 | 4 | 6 | 11 | 19:27 | -8 | 18 |
| 11 |
|
FK Borec | 21 | 3 | 4 | 14 | 17:39 | -22 | 13 |
| 12 |
|
FK Pelister | 21 | 0 | 6 | 15 | 7:33 | -26 | 6 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
