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| 08.05.2022 | 17:00 | Akademija Pandev | - | FK Rabotnički | 2:1 (2:0) | |
| 17:00 | KF Shkëndija 79 | - | KF Shkupi | 0:0 (0:0) | ||
| 17:00 | Makedonija GP | - | FC Struga | 1:3 (0:2) | ||
| 17:00 | FK Bregalnica Štip | - | GFK Tikvesh | 1:0 (1:0) | ||
| 17:00 | FK Renova | - | FK Skopje | 2:0 (0:0) | ||
| 17:00 | FK Pelister | - | FK Borec | 2:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 32 | 22 | 7 | 3 | 63:21 | 42 | 73 |
| 2 |
|
Akademija Pandev | 32 | 19 | 7 | 6 | 55:29 | 26 | 64 |
| 3 |
|
KF Shkëndija 79 | 32 | 16 | 12 | 4 | 48:24 | 24 | 60 |
| 4 |
|
Makedonija GP | 32 | 17 | 6 | 9 | 45:42 | 3 | 57 |
| 5 |
|
FC Struga | 32 | 12 | 10 | 10 | 32:32 | 0 | 46 |
| 6 |
|
FK Renova | 32 | 11 | 12 | 9 | 37:28 | 9 | 45 |
| 7 |
|
FK Bregalnica Štip | 32 | 12 | 9 | 11 | 44:43 | 1 | 45 |
| 8 |
|
FK Rabotnički | 32 | 12 | 4 | 16 | 27:34 | -7 | 40 |
| 9 |
|
FK Skopje | 32 | 8 | 8 | 16 | 23:44 | -21 | 32 |
| 10 |
|
GFK Tikvesh | 32 | 8 | 7 | 17 | 34:37 | -3 | 31 |
| 11 |
|
FK Borec | 32 | 5 | 6 | 21 | 24:61 | -37 | 21 |
| 12 |
|
FK Pelister | 32 | 2 | 8 | 22 | 15:52 | -37 | 14 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
