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| H | FK Drita | - | Sileks Kratovo | 1:2 (1:1) | ||
| R | Sileks Kratovo | - | FK Drita | 3:0 (1:0) | ||
| H: 14.10.2012 14:00 | R: 21.11.2012 14:00 | Sieger: Sileks Kratovo | ||||
| H | FK Teteks | - | FK Renova | 0:0 (0:0) | ||
| R | FK Renova | - | FK Teteks | 0:1 (0:1) | ||
| H: 14.10.2012 14:00 | R: 21.11.2012 14:00 | Sieger: FK Teteks | ||||
| H | KF Shkëndija 79 | - | Metalurg Skopje | 1:0 (1:0) | ||
| R | Metalurg Skopje | - | KF Shkëndija 79 | 1:5 (1:0) | ||
| H: 14.10.2012 14:00 | R: 21.11.2012 14:00 | Sieger: KF Shkëndija 79 | ||||
| H | FK Pelister | - | Vardar Skopje | 0:1 (0:0) | ||
| R | Vardar Skopje | - | FK Pelister | 2:0 (0:0) | ||
| H: 07.11.2012 13:00 | R: 21.11.2012 18:00 | Sieger: Vardar Skopje | ||||
