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| 18.03.2022 | 20:00 | ADO Den Haag | - | FC Volendam | 1:1 (0:0) | |
| 20:00 | Almere City FC | - | FC Den Bosch | 2:0 (2:0) | ||
| 20:00 | De Graafschap | - | MVV | 1:3 (1:1) | ||
| 20:00 | TOP Oss | - | SBV Excelsior | 1:1 (0:0) | ||
| 20:00 | Helmond Sport | - | NAC Breda | 4:0 (2:0) | ||
| 20:00 | Jong Ajax | - | FC Eindhoven | 2:2 (1:1) | ||
| 20:00 | FC Utrecht (J) | - | AZ Alkmaar (J) | 0:1 (0:1) | ||
| 20:00 | Jong PSV | - | Roda JC Kerkrade | 3:3 (3:2) | ||
| 20:00 | Telstar | - | FC Dordrecht | 1:0 (0:0) | ||
| 19.03.2022 | 16:30 | VVV-Venlo | - | FC Emmen | 0:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Emmen | 31 | 21 | 4 | 6 | 52:21 | 31 | 67 |
| 2 |
|
FC Volendam | 31 | 18 | 10 | 3 | 66:41 | 25 | 64 |
| 3 |
|
SBV Excelsior | 31 | 18 | 5 | 8 | 70:42 | 28 | 59 |
| 4 |
|
FC Eindhoven | 31 | 17 | 7 | 7 | 59:35 | 24 | 58 |
| 5 |
|
ADO Den Haag | 31 | 18 | 6 | 7 | 65:45 | 20 | 54 |
| 6 |
|
Jong Ajax | 31 | 16 | 6 | 9 | 68:54 | 14 | 54 |
| 7 |
|
Roda JC Kerkrade | 31 | 14 | 11 | 6 | 63:38 | 25 | 53 |
| 8 |
|
NAC Breda | 31 | 13 | 9 | 9 | 49:38 | 11 | 48 |
| 9 |
|
De Graafschap | 31 | 13 | 8 | 10 | 41:34 | 7 | 47 |
| 10 |
|
VVV-Venlo | 31 | 12 | 4 | 15 | 40:44 | -4 | 40 |
| 11 |
|
Jong PSV | 31 | 10 | 7 | 14 | 52:52 | 0 | 37 |
| 12 |
|
AZ Alkmaar (J) | 31 | 10 | 5 | 16 | 31:41 | -10 | 35 |
| 13 |
|
FC Den Bosch | 31 | 10 | 3 | 18 | 33:57 | -24 | 33 |
| 14 |
|
TOP Oss | 31 | 8 | 8 | 15 | 39:49 | -10 | 32 |
| 15 |
|
Almere City FC | 31 | 8 | 8 | 15 | 46:58 | -12 | 32 |
| 16 |
|
Telstar | 31 | 7 | 11 | 13 | 35:58 | -23 | 32 |
| 17 |
|
FC Dordrecht | 31 | 7 | 8 | 16 | 44:67 | -23 | 29 |
| 18 |
|
MVV | 31 | 9 | 2 | 20 | 34:64 | -30 | 29 |
| 19 |
|
FC Utrecht (J) | 31 | 8 | 4 | 19 | 31:57 | -26 | 28 |
| 20 |
|
Helmond Sport | 31 | 7 | 6 | 18 | 32:55 | -23 | 24 |
| Aufstieg | |
| Playoffs | |
| Playoffs |
|
# ADO Den Haag: -6 P. # Helmond Sport: -3 P. |
