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| 31.03.2006 | 20:00 | BV Veendam | - | FC Emmen | 2:0 (1:0) | |
| 20:00 | AGOVV | - | HFC Haarlem | 0:1 (0:0) | ||
| 20:00 | FC Eindhoven | - | SC Cambuur | 3:3 (2:3) | ||
| 20:00 | FC Volendam | - | FC Omniworld | 2:0 (1:0) | ||
| 20:00 | FC Dordrecht | - | Helmond Sport | 0:2 (0:1) | ||
| 20:00 | De Graafschap | - | TOP Oss | 2:0 (1:0) | ||
| 20:00 | FC Den Bosch | - | Fortuna Sittard | 4:1 (1:0) | ||
| 20:00 | Go Ahead Eagles | - | Stormvogels Telstar | 2:1 (1:0) | ||
| 20:00 | MVV | - | FC Zwolle | 2:0 (1:0) | ||
| 20:00 | SBV Excelsior | - | VVV-Venlo | 3:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SBV Excelsior | 37 | 22 | 8 | 7 | 67:24 | 43 | 74 |
| 2 |
|
VVV-Venlo | 37 | 19 | 8 | 10 | 50:34 | 16 | 65 |
| 3 |
|
Helmond Sport | 37 | 19 | 7 | 11 | 62:53 | 9 | 64 |
| 4 |
|
FC Volendam | 37 | 18 | 9 | 10 | 57:42 | 15 | 63 |
| 5 |
|
FC Den Bosch | 37 | 16 | 11 | 10 | 62:50 | 12 | 59 |
| 6 |
|
De Graafschap | 37 | 16 | 11 | 10 | 60:49 | 11 | 59 |
| 7 |
|
HFC Haarlem | 37 | 17 | 7 | 13 | 57:51 | 6 | 58 |
| 8 |
|
FC Emmen | 37 | 17 | 6 | 14 | 65:55 | 10 | 57 |
| 9 |
|
AGOVV | 37 | 17 | 5 | 15 | 63:59 | 4 | 56 |
| 10 |
|
TOP Oss | 37 | 15 | 10 | 12 | 50:51 | -1 | 55 |
| 11 |
|
FC Zwolle | 37 | 15 | 9 | 13 | 55:49 | 6 | 54 |
| 12 |
|
FC Dordrecht | 37 | 14 | 11 | 12 | 57:43 | 14 | 53 |
| 13 |
|
MVV | 37 | 13 | 11 | 13 | 53:52 | 1 | 50 |
| 14 |
|
BV Veendam | 37 | 13 | 9 | 15 | 52:60 | -8 | 48 |
| 15 |
|
SC Cambuur | 37 | 11 | 14 | 12 | 47:50 | -3 | 44 |
| 16 |
|
FC Eindhoven | 37 | 11 | 6 | 20 | 52:62 | -10 | 39 |
| 17 |
|
Stormvogels Telstar | 37 | 8 | 13 | 16 | 34:52 | -18 | 37 |
| 18 |
|
Go Ahead Eagles | 37 | 8 | 11 | 18 | 45:67 | -22 | 35 |
| 19 |
|
FC Omniworld | 37 | 7 | 8 | 22 | 48:83 | -35 | 29 |
| 20 |
|
Fortuna Sittard | 37 | 2 | 10 | 25 | 34:84 | -50 | 16 |
| Aufstieg |
|
# Cambuur-Leeuwarden bekam 3 Punkte abgezogen. |
