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| H | Veraguas Club Deportivo | - | Herrera FC | 1:1 (1:1) | ||
| R | Herrera FC | - | Veraguas Club Deportivo | 1:0 (0:0) | ||
| H: 28.11.2021 01:00 | R: 06.12.2021 00:00 | Sieger: Herrera FC | ||||
| H | Alianza | - | Tauro FC | 0:0 (0:0) | ||
| R | Tauro FC | - | Alianza | 1:0 (1:0) | ||
| H: 30.11.2021 01:00 | R: 05.12.2021 23:00 | Sieger: Tauro FC | ||||
