 |
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| 27.09.2022 | 22:30 | Guaireña FC | - | Sportivo Ameliano | 0:2 | |
| 28.09.2022 | 01:00 | 12 de Octubre de Itauguá | - | Atlético Tembetary | 1:2 | |
| 22:30 | Club Nacional | - | Tacuary | 2:0 | ||
| 29.09.2022 | 01:00 | Libertad | - | Guaraní | 4:5 i.E. |
|
|
|
|
| 27.09.2022 | 22:30 | Guaireña FC | - | Sportivo Ameliano | 0:2 | |
| 28.09.2022 | 01:00 | 12 de Octubre de Itauguá | - | Atlético Tembetary | 1:2 | |
| 22:30 | Club Nacional | - | Tacuary | 2:0 | ||
| 29.09.2022 | 01:00 | Libertad | - | Guaraní | 4:5 i.E. |
