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| 17.12.2021 | 18:00 | Wisła Kraków | - | Bruk-Bet Termalica Nieciecza | 3:0 (2:0) | |
| 20:30 | Wisła Płock | - | Lechia Gdańsk | 1:0 (1:0) | ||
| 18.12.2021 | 12:30 | Piast Gliwice | - | FKS Stal Mielec | 1:1 (1:0) | |
| 15:00 | Pogoń Szczecin | - | Warta Poznań | 1:1 (0:0) | ||
| 17:30 | Śląsk Wrocław | - | KS Cracovia | 0:2 (0:1) | ||
| 20:00 | Raków Częstochowa | - | Jagiellonia Białystok | 5:0 (0:0) | ||
| 19.12.2021 | 12:30 | Górnik Łęczna | - | Zagłębie Lubin | 2:1 (0:1) | |
| 15:00 | Lech Poznań | - | Górnik Zabrze | 2:1 (1:1) | ||
| 17:30 | Legia Warszawa | - | Radomiak Radom | 0:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Lech Poznań | 19 | 12 | 5 | 2 | 37:13 | 24 | 41 |
| 2 |
|
Pogoń Szczecin | 19 | 10 | 7 | 2 | 35:16 | 19 | 37 |
| 3 |
|
Raków Częstochowa | 19 | 10 | 5 | 4 | 36:22 | 14 | 35 |
| 4 |
|
Radomiak Radom | 19 | 9 | 8 | 2 | 28:16 | 12 | 35 |
| 5 |
|
Lechia Gdańsk | 19 | 9 | 6 | 4 | 33:23 | 10 | 33 |
| 6 |
|
Wisła Płock | 19 | 9 | 2 | 8 | 29:26 | 3 | 29 |
| 7 |
|
Górnik Zabrze | 19 | 8 | 4 | 7 | 27:26 | 1 | 28 |
| 8 |
|
FKS Stal Mielec | 19 | 7 | 7 | 5 | 26:26 | 0 | 28 |
| 9 |
|
KS Cracovia | 19 | 7 | 5 | 7 | 25:26 | -1 | 26 |
| 10 |
|
Śląsk Wrocław | 19 | 6 | 6 | 7 | 30:30 | 0 | 24 |
| 11 |
|
Jagiellonia Białystok | 19 | 6 | 6 | 7 | 24:31 | -7 | 24 |
| 12 |
|
Piast Gliwice | 19 | 6 | 5 | 8 | 26:26 | 0 | 23 |
| 13 |
|
Wisła Kraków | 19 | 6 | 3 | 10 | 21:30 | -9 | 21 |
| 14 |
|
Zagłębie Lubin | 19 | 6 | 2 | 11 | 20:36 | -16 | 20 |
| 15 |
|
Legia Warszawa | 19 | 6 | 0 | 13 | 23:31 | -8 | 18 |
| 16 |
|
Górnik Łęczna | 19 | 4 | 6 | 9 | 19:36 | -17 | 18 |
| 17 |
|
Warta Poznań | 19 | 3 | 7 | 9 | 14:24 | -10 | 16 |
| 18 |
|
Bruk-Bet Termalica Nieciecza | 19 | 2 | 6 | 11 | 21:36 | -15 | 12 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
