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| 04.03.2022 | 19:00 | SC Eltersdorf | - | SpVgg Bayreuth | 0:3 (0:0) | |
| 05.03.2022 | 13:00 | Bayern München II | - | SV Schalding-Heining | 1:0 (0:0) | |
| 14:00 | FC Memmingen | - | SpVgg Unterhaching | 0:2 (0:0) | ||
| 14:00 | FC Augsburg II | - | Viktoria Aschaffenburg | 0:2 (0:0) | ||
| 14:00 | FV Illertissen | - | FC Pipinsried | 1:0 (0:0) | ||
| 14:00 | SV Heimstetten | - | 1. FC Schweinfurt 05 | 2:2 (0:1) | ||
| 14:00 | TSV Aubstadt | - | SpVgg Greuther Fürth II | 0:0 (0:0) | ||
| 14:00 | VfB Eichstätt | - | TSV 1860 Rosenheim | 2:0 (0:0) | ||
| 14:00 | Wacker Burghausen | - | TSV 1896 Rain | 3:2 (3:1) | ||
| 06.03.2022 | 14:30 | 1. FC Nürnberg II | - | TSV Buchbach | 1:0 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SpVgg Bayreuth | 27 | 22 | 2 | 3 | 72:24 | 48 | 68 |
| 2 |
|
Bayern München II | 27 | 18 | 7 | 2 | 84:33 | 51 | 61 |
| 3 |
|
FV Illertissen | 27 | 15 | 6 | 6 | 48:27 | 21 | 51 |
| 4 |
|
1. FC Schweinfurt 05 | 27 | 13 | 9 | 5 | 79:35 | 44 | 48 |
| 5 |
|
Wacker Burghausen | 27 | 14 | 4 | 9 | 60:41 | 19 | 46 |
| 6 |
|
TSV Aubstadt | 27 | 12 | 8 | 7 | 49:31 | 18 | 44 |
| 7 |
|
SpVgg Unterhaching | 27 | 12 | 7 | 8 | 54:48 | 6 | 43 |
| 8 |
|
VfB Eichstätt | 27 | 12 | 4 | 11 | 41:47 | -6 | 40 |
| 9 |
|
TSV Buchbach | 27 | 10 | 8 | 9 | 37:31 | 6 | 38 |
| 10 |
|
Viktoria Aschaffenburg | 27 | 10 | 5 | 12 | 37:40 | -3 | 35 |
| 11 |
|
1. FC Nürnberg II | 27 | 8 | 10 | 9 | 38:40 | -2 | 34 |
| 12 |
|
FC Augsburg II | 27 | 9 | 7 | 11 | 43:50 | -7 | 34 |
| 13 |
|
FC Pipinsried | 27 | 9 | 4 | 14 | 35:53 | -18 | 31 |
| 14 |
|
SC Eltersdorf | 27 | 9 | 3 | 15 | 42:62 | -20 | 30 |
| 15 |
|
FC Memmingen | 27 | 7 | 7 | 13 | 37:57 | -20 | 28 |
| 16 |
|
SV Schalding-Heining | 27 | 7 | 6 | 14 | 31:47 | -16 | 27 |
| 17 |
|
TSV 1896 Rain | 27 | 8 | 3 | 16 | 24:55 | -31 | 27 |
| 18 |
|
SV Heimstetten | 27 | 7 | 4 | 16 | 39:57 | -18 | 25 |
| 19 |
|
SpVgg Greuther Fürth II | 27 | 5 | 8 | 14 | 33:57 | -24 | 23 |
| 20 |
|
TSV 1860 Rosenheim | 27 | 3 | 8 | 16 | 24:72 | -48 | 17 |
| Aufstieg | |
| Relegation | |
| Abstieg |
