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| 19.01.2021 | 19:00 | Bayern Alzenau | - | VfB Stuttgart II | 1:4 (1:3) | |
| 19:00 | 1. FSV Mainz 05 II | - | FC-Astoria Walldorf | 0:2 (0:2) | ||
| 19:00 | 1899 Hoffenheim II | - | FC 08 Homburg | 0:0 (0:0) | ||
| 19:00 | VfR Aalen | - | FK Pirmasens | 1:1 (0:1) | ||
| 20.01.2021 | 14:00 | Bahlinger SC | - | FSV Frankfurt | 0:0 (0:0) | |
| 17:30 | TSG Balingen | - | Hessen Kassel | 2:0 (1:0) | ||
| 18:00 | Eintracht Stadtallendorf | - | TSV Steinbach Haiger | 0:1 (0:1) | ||
| 19:00 | Kickers Offenbach | - | SV 07 Elversberg | 0:0 (0:0) | ||
| 19:00 | SSV Ulm 1846 | - | FC Gießen | 2:3 (1:0) | ||
| 23.02.2021 | 14:00 | SC Freiburg II | - | TSV Schott Mainz | 4:1 (3:0) | |
| 24.02.2021 | 18:00 | SG Sonnenhof Großaspach | - | Rot-Weiß Koblenz | 0:2 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 16 | 11 | 2 | 3 | 43:18 | 25 | 35 |
| 2 |
|
Kickers Offenbach | 16 | 9 | 5 | 2 | 31:10 | 21 | 32 |
| 3 |
|
TSV Steinbach Haiger | 16 | 10 | 2 | 4 | 34:16 | 18 | 32 |
| 4 |
|
TSG Balingen | 16 | 9 | 4 | 3 | 28:16 | 12 | 31 |
| 5 |
|
FSV Frankfurt | 16 | 9 | 3 | 4 | 24:17 | 7 | 30 |
| 6 |
|
SV 07 Elversberg | 16 | 8 | 5 | 3 | 34:17 | 17 | 29 |
| 7 |
|
SSV Ulm 1846 | 16 | 8 | 4 | 4 | 30:14 | 16 | 28 |
| 8 |
|
FC 08 Homburg | 16 | 7 | 4 | 5 | 30:20 | 10 | 25 |
| 9 |
|
VfB Stuttgart II | 16 | 7 | 3 | 6 | 29:21 | 8 | 24 |
| 10 |
|
Bahlinger SC | 16 | 6 | 4 | 6 | 27:34 | -7 | 22 |
| 11 |
|
FK Pirmasens | 16 | 5 | 5 | 6 | 13:24 | -11 | 20 |
| 12 |
|
1899 Hoffenheim II | 16 | 5 | 4 | 7 | 20:25 | -5 | 19 |
| 13 |
|
1. FSV Mainz 05 II | 16 | 5 | 4 | 7 | 18:27 | -9 | 19 |
|
VfR Aalen | 16 | 5 | 4 | 7 | 18:27 | -9 | 19 | |
| 15 |
|
FC-Astoria Walldorf | 16 | 5 | 3 | 8 | 22:28 | -6 | 18 |
| 16 |
|
Rot-Weiß Koblenz | 16 | 5 | 3 | 8 | 15:24 | -9 | 18 |
| 17 |
|
SG Sonnenhof Großaspach | 16 | 5 | 3 | 8 | 19:30 | -11 | 18 |
| 18 |
|
FC Gießen | 16 | 5 | 2 | 9 | 17:24 | -7 | 17 |
| 19 |
|
Bayern Alzenau | 16 | 5 | 2 | 9 | 18:30 | -12 | 17 |
| 20 |
|
TSV Schott Mainz | 16 | 5 | 1 | 10 | 26:42 | -16 | 16 |
| 21 |
|
Hessen Kassel | 16 | 3 | 6 | 7 | 22:32 | -10 | 15 |
| 22 |
|
Eintracht Stadtallendorf | 16 | 1 | 3 | 12 | 14:36 | -22 | 6 |
| Aufstieg | |
| Abstieg |
