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| 12.02.2021 | 15:00 | TSG Balingen | - | 1. FSV Mainz 05 II | 2:5 (0:3) | |
| 13.02.2021 | 14:00 | Kickers Offenbach | - | SG Sonnenhof Großaspach | 3:1 (1:1) | |
| 14:00 | 1899 Hoffenheim II | - | Bahlinger SC | 0:4 (0:2) | ||
| 14.02.2021 | 14:00 | VfB Stuttgart II | - | FC 08 Homburg | 2:2 (1:2) | |
| 24.02.2021 | 14:00 | TSV Steinbach Haiger | - | VfR Aalen | 3:3 (2:0) | |
| 15:30 | FC Gießen | - | SV 07 Elversberg | 0:2 (0:1) | ||
| 03.03.2021 | 19:00 | SSV Ulm 1846 | - | Rot-Weiß Koblenz | 1:1 (1:0) | |
| 09.03.2021 | 18:30 | TSV Schott Mainz | - | Hessen Kassel | 1:0 (0:0) | |
| 10.03.2021 | 14:00 | SC Freiburg II | - | FC-Astoria Walldorf | 3:1 (1:0) | |
| 30.03.2021 | 19:00 | FK Pirmasens | - | Eintracht Stadtallendorf | 2:0 (1:0) | |
| 06.04.2021 | 17:30 | Bayern Alzenau | - | FSV Frankfurt | 1:2 (1:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 23 | 14 | 6 | 3 | 57:26 | 31 | 48 |
| 2 |
|
FSV Frankfurt | 23 | 13 | 6 | 4 | 36:23 | 13 | 45 |
| 3 |
|
TSV Steinbach Haiger | 23 | 13 | 5 | 5 | 47:27 | 20 | 44 |
| 4 |
|
Kickers Offenbach | 23 | 11 | 9 | 3 | 41:15 | 26 | 42 |
| 5 |
|
SSV Ulm 1846 | 23 | 11 | 7 | 5 | 43:22 | 21 | 40 |
| 6 |
|
SV 07 Elversberg | 23 | 10 | 9 | 4 | 47:28 | 19 | 39 |
| 7 |
|
VfB Stuttgart II | 23 | 10 | 6 | 7 | 48:26 | 22 | 36 |
| 8 |
|
TSG Balingen | 23 | 10 | 5 | 8 | 36:30 | 6 | 35 |
| 9 |
|
Bahlinger SC | 23 | 9 | 6 | 8 | 37:45 | -8 | 33 |
| 10 |
|
FC 08 Homburg | 23 | 8 | 8 | 7 | 42:34 | 8 | 32 |
| 11 |
|
1. FSV Mainz 05 II | 23 | 8 | 6 | 9 | 30:34 | -4 | 30 |
| 12 |
|
Rot-Weiß Koblenz | 23 | 8 | 5 | 10 | 26:34 | -8 | 29 |
| 13 |
|
FK Pirmasens | 23 | 7 | 8 | 8 | 22:37 | -15 | 29 |
| 14 |
|
VfR Aalen | 23 | 7 | 7 | 9 | 27:35 | -8 | 28 |
| 15 |
|
FC Gießen | 23 | 7 | 6 | 10 | 24:30 | -6 | 27 |
| 16 |
|
SG Sonnenhof Großaspach | 23 | 7 | 5 | 11 | 29:37 | -8 | 26 |
| 17 |
|
Hessen Kassel | 23 | 6 | 8 | 9 | 31:41 | -10 | 26 |
| 18 |
|
1899 Hoffenheim II | 23 | 7 | 4 | 12 | 29:43 | -14 | 25 |
| 19 |
|
TSV Schott Mainz | 23 | 7 | 4 | 12 | 33:56 | -23 | 25 |
| 20 |
|
FC-Astoria Walldorf | 23 | 6 | 4 | 13 | 28:41 | -13 | 22 |
| 21 |
|
Bayern Alzenau | 23 | 5 | 6 | 12 | 28:45 | -17 | 21 |
| 22 |
|
Eintracht Stadtallendorf | 23 | 1 | 6 | 16 | 19:51 | -32 | 9 |
| Aufstieg | |
| Abstieg |
