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| 27.02.2021 | 14:00 | Eintracht Stadtallendorf | - | FC 08 Homburg | 1:2 (1:0) | |
| 14:00 | Bayern Alzenau | - | VfR Aalen | 0:1 (0:1) | ||
| 14:00 | FC Gießen | - | FSV Frankfurt | 0:1 (0:0) | ||
| 14:00 | FK Pirmasens | - | Hessen Kassel | 3:2 (3:0) | ||
| 14:00 | SSV Ulm 1846 | - | FC-Astoria Walldorf | 1:0 (0:0) | ||
| 14:00 | TSG Balingen | - | SG Sonnenhof Großaspach | 1:1 (1:1) | ||
| 14:00 | 1899 Hoffenheim II | - | Kickers Offenbach | 0:1 (0:0) | ||
| 14:00 | TSV Schott Mainz | - | SV 07 Elversberg | 0:6 (0:3) | ||
| 14:00 | TSV Steinbach Haiger | - | Bahlinger SC | 2:0 (1:0) | ||
| 28.02.2021 | 14:00 | VfB Stuttgart II | - | Rot-Weiß Koblenz | 2:1 (1:0) | |
| 14:00 | SC Freiburg II | - | 1. FSV Mainz 05 II | 3:1 (1:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 25 | 16 | 6 | 3 | 63:28 | 35 | 54 |
| 2 |
|
Kickers Offenbach | 25 | 13 | 9 | 3 | 43:15 | 28 | 48 |
| 3 |
|
TSV Steinbach Haiger | 25 | 14 | 6 | 5 | 50:28 | 22 | 48 |
| 4 |
|
FSV Frankfurt | 25 | 14 | 6 | 5 | 38:26 | 12 | 48 |
| 5 |
|
SSV Ulm 1846 | 25 | 13 | 7 | 5 | 47:23 | 24 | 46 |
| 6 |
|
SV 07 Elversberg | 25 | 12 | 9 | 4 | 57:28 | 29 | 45 |
| 7 |
|
VfB Stuttgart II | 25 | 11 | 6 | 8 | 50:31 | 19 | 39 |
| 8 |
|
FC 08 Homburg | 25 | 10 | 8 | 7 | 46:36 | 10 | 38 |
| 9 |
|
TSG Balingen | 25 | 10 | 6 | 9 | 37:33 | 4 | 36 |
| 10 |
|
Bahlinger SC | 25 | 10 | 6 | 9 | 39:47 | -8 | 36 |
| 11 |
|
FK Pirmasens | 25 | 8 | 8 | 9 | 25:40 | -15 | 32 |
| 12 |
|
1. FSV Mainz 05 II | 25 | 8 | 7 | 10 | 32:38 | -6 | 31 |
| 13 |
|
VfR Aalen | 25 | 8 | 7 | 10 | 29:38 | -9 | 31 |
| 14 |
|
Rot-Weiß Koblenz | 25 | 8 | 6 | 11 | 28:37 | -9 | 30 |
| 15 |
|
Hessen Kassel | 25 | 7 | 8 | 10 | 36:45 | -9 | 29 |
| 16 |
|
FC Gießen | 25 | 7 | 7 | 11 | 25:32 | -7 | 28 |
| 17 |
|
SG Sonnenhof Großaspach | 25 | 7 | 7 | 11 | 33:41 | -8 | 28 |
| 18 |
|
1899 Hoffenheim II | 25 | 7 | 5 | 13 | 32:47 | -15 | 26 |
| 19 |
|
FC-Astoria Walldorf | 25 | 7 | 4 | 14 | 30:42 | -12 | 25 |
| 20 |
|
TSV Schott Mainz | 25 | 7 | 4 | 14 | 34:64 | -30 | 25 |
| 21 |
|
Bayern Alzenau | 25 | 5 | 6 | 14 | 28:48 | -20 | 21 |
| 22 |
|
Eintracht Stadtallendorf | 25 | 1 | 6 | 18 | 21:56 | -35 | 9 |
| Aufstieg | |
| Abstieg |
