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| 15.05.2021 | 14:00 | Bahlinger SC | - | FC-Astoria Walldorf | 2:2 (1:0) | |
| 14:00 | Bayern Alzenau | - | TSV Schott Mainz | 0:3 (0:1) | ||
| 14:00 | FC Gießen | - | FK Pirmasens | 1:0 (0:0) | ||
| 14:00 | Kickers Offenbach | - | Rot-Weiß Koblenz | 4:2 (2:1) | ||
| 14:00 | SG Sonnenhof Großaspach | - | FSV Frankfurt | 0:2 (0:1) | ||
| 14:00 | SSV Ulm 1846 | - | VfB Stuttgart II | 2:0 (0:0) | ||
| 14:00 | TSG Balingen | - | FC 08 Homburg | 1:0 (1:0) | ||
| 14:00 | 1899 Hoffenheim II | - | SV 07 Elversberg | 0:2 (0:2) | ||
| 14:00 | TSV Steinbach Haiger | - | Hessen Kassel | 1:1 (1:0) | ||
| 16.05.2021 | 14:00 | 1. FSV Mainz 05 II | - | VfR Aalen | 3:1 (1:1) | |
| 14:00 | SC Freiburg II | - | Eintracht Stadtallendorf | 5:1 (2:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 38 | 27 | 7 | 4 | 92:36 | 56 | 88 |
| 2 |
|
SV 07 Elversberg | 38 | 22 | 12 | 4 | 91:40 | 51 | 78 |
| 3 |
|
Kickers Offenbach | 38 | 22 | 11 | 5 | 71:31 | 40 | 77 |
| 4 |
|
SSV Ulm 1846 | 38 | 22 | 9 | 7 | 69:32 | 37 | 75 |
| 5 |
|
TSV Steinbach Haiger | 38 | 21 | 10 | 7 | 78:36 | 42 | 73 |
| 6 |
|
FSV Frankfurt | 38 | 20 | 8 | 10 | 55:42 | 13 | 68 |
| 7 |
|
FC 08 Homburg | 38 | 14 | 14 | 10 | 64:52 | 12 | 56 |
| 8 |
|
VfB Stuttgart II | 38 | 16 | 7 | 15 | 67:50 | 17 | 55 |
| 9 |
|
Bahlinger SC | 38 | 15 | 9 | 14 | 60:70 | -10 | 54 |
| 10 |
|
Rot-Weiß Koblenz | 38 | 14 | 10 | 14 | 51:53 | -2 | 52 |
| 11 |
|
1. FSV Mainz 05 II | 38 | 13 | 10 | 15 | 57:67 | -10 | 49 |
| 12 |
|
VfR Aalen | 38 | 12 | 12 | 14 | 42:52 | -10 | 48 |
| 13 |
|
Hessen Kassel | 38 | 11 | 13 | 14 | 52:67 | -15 | 46 |
| 14 |
|
TSG Balingen | 38 | 12 | 9 | 17 | 46:57 | -11 | 45 |
| 15 |
|
FC Gießen | 38 | 10 | 13 | 15 | 40:48 | -8 | 43 |
| 16 |
|
1899 Hoffenheim II | 38 | 11 | 10 | 17 | 50:67 | -17 | 43 |
| 17 |
|
FK Pirmasens | 38 | 10 | 13 | 15 | 36:55 | -19 | 43 |
| 18 |
|
FC-Astoria Walldorf | 38 | 12 | 5 | 21 | 57:68 | -11 | 41 |
| 19 |
|
TSV Schott Mainz | 38 | 11 | 5 | 22 | 52:89 | -37 | 38 |
| 20 |
|
SG Sonnenhof Großaspach | 38 | 9 | 10 | 19 | 46:68 | -22 | 37 |
| 21 |
|
Bayern Alzenau | 38 | 5 | 9 | 24 | 44:84 | -40 | 24 |
| 22 |
|
Eintracht Stadtallendorf | 38 | 3 | 6 | 29 | 33:89 | -56 | 15 |
| Aufstieg | |
| Abstieg |
