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| 21.05.2021 | 19:00 | Eintracht Stadtallendorf | - | Bayern Alzenau | 3:3 (1:1) | |
| 19:00 | SV 07 Elversberg | - | TSG Balingen | 1:0 (1:0) | ||
| 22.05.2021 | 14:00 | FC 08 Homburg | - | TSV Steinbach Haiger | 3:1 (0:0) | |
| 14:00 | FC-Astoria Walldorf | - | SG Sonnenhof Großaspach | 2:1 (1:0) | ||
| 14:00 | FK Pirmasens | - | 1. FSV Mainz 05 II | 2:0 (0:0) | ||
| 14:00 | FSV Frankfurt | - | Kickers Offenbach | 0:0 (0:0) | ||
| 14:00 | Hessen Kassel | - | SC Freiburg II | 0:0 (0:0) | ||
| 14:00 | Rot-Weiß Koblenz | - | 1899 Hoffenheim II | 2:2 (1:0) | ||
| 14:00 | TSV Schott Mainz | - | SSV Ulm 1846 | 1:3 (1:1) | ||
| 14:00 | VfB Stuttgart II | - | FC Gießen | 1:1 (0:1) | ||
| 14:00 | VfR Aalen | - | Bahlinger SC | 1:1 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SC Freiburg II | 39 | 27 | 8 | 4 | 92:36 | 56 | 89 |
| 2 |
|
SV 07 Elversberg | 39 | 23 | 12 | 4 | 92:40 | 52 | 81 |
| 3 |
|
Kickers Offenbach | 39 | 22 | 12 | 5 | 71:31 | 40 | 78 |
| 4 |
|
SSV Ulm 1846 | 39 | 23 | 9 | 7 | 72:33 | 39 | 78 |
| 5 |
|
TSV Steinbach Haiger | 39 | 21 | 10 | 8 | 79:39 | 40 | 73 |
| 6 |
|
FSV Frankfurt | 39 | 20 | 9 | 10 | 55:42 | 13 | 69 |
| 7 |
|
FC 08 Homburg | 39 | 15 | 14 | 10 | 67:53 | 14 | 59 |
| 8 |
|
VfB Stuttgart II | 39 | 16 | 8 | 15 | 68:51 | 17 | 56 |
| 9 |
|
Bahlinger SC | 39 | 15 | 10 | 14 | 61:71 | -10 | 55 |
| 10 |
|
Rot-Weiß Koblenz | 39 | 14 | 11 | 14 | 53:55 | -2 | 53 |
| 11 |
|
VfR Aalen | 39 | 12 | 13 | 14 | 43:53 | -10 | 49 |
| 12 |
|
1. FSV Mainz 05 II | 39 | 13 | 10 | 16 | 57:69 | -12 | 49 |
| 13 |
|
Hessen Kassel | 39 | 11 | 14 | 14 | 52:67 | -15 | 47 |
| 14 |
|
FK Pirmasens | 39 | 11 | 13 | 15 | 38:55 | -17 | 46 |
| 15 |
|
TSG Balingen | 39 | 12 | 9 | 18 | 46:58 | -12 | 45 |
| 16 |
|
FC Gießen | 39 | 10 | 14 | 15 | 41:49 | -8 | 44 |
| 17 |
|
FC-Astoria Walldorf | 39 | 13 | 5 | 21 | 59:69 | -10 | 44 |
| 18 |
|
1899 Hoffenheim II | 39 | 11 | 11 | 17 | 52:69 | -17 | 44 |
| 19 |
|
TSV Schott Mainz | 39 | 11 | 5 | 23 | 53:92 | -39 | 38 |
| 20 |
|
SG Sonnenhof Großaspach | 39 | 9 | 10 | 20 | 47:70 | -23 | 37 |
| 21 |
|
Bayern Alzenau | 39 | 5 | 10 | 24 | 47:87 | -40 | 25 |
| 22 |
|
Eintracht Stadtallendorf | 39 | 3 | 7 | 29 | 36:92 | -56 | 16 |
| Aufstieg | |
| Abstieg |
