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| 31.10.2020 | 14:00 | Fortuna Düsseldorf II | - | Rot Weiss Ahlen | 4:1 (2:1) | |
| 14:00 | Fortuna Köln | - | Borussia Dortmund II | 1:2 (0:2) | ||
| 14:00 | Rot-Weiß Oberhausen | - | SC Wiedenbrück | 3:3 (0:1) | ||
| 14:00 | SV Bergisch Gladbach 09 | - | 1. FC Köln II | 2:2 (2:1) | ||
| 14:00 | SV Lippstadt 08 | - | FC Wegberg-Beeck | 1:2 (1:0) | ||
| 14:00 | SV Rödinghausen | - | Sportfreunde Lotte | 4:2 (1:1) | ||
| 14:00 | VfB Homberg | - | Wuppertaler SV | 2:1 (1:1) | ||
| 15:30 | FC Schalke 04 II | - | Rot-Weiss Essen | 1:1 (0:0) | ||
| 16.12.2020 | 16:00 | Bor. Mönchengladbach II | - | Bonner SC | 2:0 (2:0) | |
| 09.01.2021 | 14:00 | SV 19 Straelen | - | Alemannia Aachen | 0:0 (0:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 11 | 8 | 3 | 0 | 27:8 | 19 | 27 |
| 2 |
|
Rot-Weiss Essen | 11 | 7 | 4 | 0 | 19:6 | 13 | 25 |
| 3 |
|
Preußen Münster | 11 | 7 | 2 | 2 | 19:9 | 10 | 23 |
| 4 |
|
Fortuna Düsseldorf II | 11 | 6 | 4 | 1 | 24:6 | 18 | 22 |
| 5 |
|
Fortuna Köln | 11 | 6 | 3 | 2 | 23:13 | 10 | 21 |
| 6 |
|
Bor. Mönchengladbach II | 12 | 6 | 2 | 4 | 23:14 | 9 | 20 |
| 7 |
|
1. FC Köln II | 11 | 4 | 5 | 2 | 16:12 | 4 | 17 |
| 8 |
|
FC Schalke 04 II | 12 | 4 | 5 | 3 | 12:8 | 4 | 17 |
| 9 |
|
SV Rödinghausen | 12 | 4 | 5 | 3 | 15:12 | 3 | 17 |
| 10 |
|
SV 19 Straelen | 12 | 4 | 5 | 3 | 16:14 | 2 | 17 |
| 11 |
|
Alemannia Aachen | 12 | 4 | 4 | 4 | 8:9 | -1 | 16 |
| 12 |
|
SV Bergisch Gladbach 09 | 12 | 3 | 4 | 5 | 11:16 | -5 | 13 |
| 13 |
|
FC Wegberg-Beeck | 11 | 3 | 3 | 5 | 12:15 | -3 | 12 |
| 14 |
|
SC Wiedenbrück | 11 | 2 | 6 | 3 | 17:22 | -5 | 12 |
| 15 |
|
Wuppertaler SV | 12 | 3 | 3 | 6 | 13:21 | -8 | 12 |
| 16 |
|
Rot-Weiß Oberhausen | 12 | 2 | 5 | 5 | 12:21 | -9 | 11 |
| 17 |
|
SV Lippstadt 08 | 11 | 1 | 6 | 4 | 9:16 | -7 | 9 |
| 18 |
|
Sportfreunde Lotte | 11 | 2 | 3 | 6 | 13:27 | -14 | 9 |
| 19 |
|
Bonner SC | 11 | 2 | 2 | 7 | 10:20 | -10 | 8 |
| 20 |
|
VfB Homberg | 12 | 2 | 1 | 9 | 9:25 | -16 | 7 |
| 21 |
|
Rot Weiss Ahlen | 11 | 1 | 3 | 7 | 13:27 | -14 | 6 |
| Aufstieg | |
| Abstieg |
