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| 16.01.2021 | 14:00 | Bonner SC | - | Sportfreunde Lotte | 0:1 (0:0) | |
| 14:00 | Fortuna Düsseldorf II | - | SV 19 Straelen | 0:2 (0:2) | ||
| 14:00 | Fortuna Köln | - | SV Bergisch Gladbach 09 | 3:0 (0:0) | ||
| 14:00 | Preußen Münster | - | SV Rödinghausen | 2:0 (0:0) | ||
| 14:00 | Rot Weiss Ahlen | - | Wuppertaler SV | 0:1 (0:0) | ||
| 14:00 | Rot-Weiß Oberhausen | - | FC Wegberg-Beeck | 5:0 (3:0) | ||
| 14:00 | SC Wiedenbrück | - | Rot-Weiss Essen | 0:0 (0:0) | ||
| 14:00 | SV Lippstadt 08 | - | VfB Homberg | 3:1 (1:0) | ||
| 17.01.2021 | 15:00 | Borussia Dortmund II | - | Alemannia Aachen | 2:1 (1:1) | |
| 10.03.2021 | 14:00 | Bor. Mönchengladbach II | - | FC Schalke 04 II | 0:1 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rot-Weiss Essen | 21 | 15 | 6 | 0 | 46:12 | 34 | 51 |
| 2 |
|
Borussia Dortmund II | 21 | 15 | 5 | 1 | 55:16 | 39 | 50 |
| 3 |
|
Fortuna Köln | 21 | 11 | 7 | 3 | 42:23 | 19 | 40 |
| 4 |
|
Preußen Münster | 21 | 11 | 4 | 6 | 30:19 | 11 | 37 |
| 5 |
|
Fortuna Düsseldorf II | 21 | 10 | 5 | 6 | 40:21 | 19 | 35 |
| 6 |
|
FC Schalke 04 II | 21 | 8 | 9 | 4 | 28:21 | 7 | 33 |
| 7 |
|
1. FC Köln II | 20 | 8 | 8 | 4 | 29:20 | 9 | 32 |
| 8 |
|
Bor. Mönchengladbach II | 21 | 9 | 5 | 7 | 31:25 | 6 | 32 |
| 9 |
|
Alemannia Aachen | 21 | 8 | 6 | 7 | 19:17 | 2 | 30 |
| 10 |
|
SV Rödinghausen | 21 | 8 | 5 | 8 | 26:24 | 2 | 29 |
| 11 |
|
SV 19 Straelen | 21 | 7 | 7 | 7 | 25:32 | -7 | 28 |
| 12 |
|
Rot-Weiß Oberhausen | 21 | 6 | 9 | 6 | 31:28 | 3 | 27 |
| 13 |
|
SC Wiedenbrück | 21 | 5 | 11 | 5 | 29:29 | 0 | 26 |
| 14 |
|
SV Lippstadt 08 | 21 | 4 | 10 | 7 | 23:34 | -11 | 22 |
| 15 |
|
Wuppertaler SV | 21 | 6 | 4 | 11 | 22:37 | -15 | 22 |
| 16 |
|
FC Wegberg-Beeck | 21 | 5 | 6 | 10 | 22:34 | -12 | 21 |
| 17 |
|
SV Bergisch Gladbach 09 | 21 | 4 | 6 | 11 | 19:39 | -20 | 18 |
| 18 |
|
VfB Homberg | 21 | 5 | 3 | 13 | 19:41 | -22 | 18 |
| 19 |
|
Sportfreunde Lotte | 21 | 4 | 5 | 12 | 18:41 | -23 | 17 |
| 20 |
|
Rot Weiss Ahlen | 21 | 2 | 7 | 12 | 23:41 | -18 | 13 |
| 21 |
|
Bonner SC | 21 | 3 | 4 | 14 | 19:42 | -23 | 13 |
| Aufstieg | |
| Abstieg |
