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| 20.03.2021 | 14:00 | Alemannia Aachen | - | SV Rödinghausen | 0:0 (0:0) | |
| 14:00 | Bonner SC | - | Fortuna Köln | 1:2 (0:2) | ||
| 14:00 | Borussia Dortmund II | - | SV Lippstadt 08 | 2:0 (1:0) | ||
| 14:00 | FC Wegberg-Beeck | - | Rot Weiss Ahlen | 2:1 (1:1) | ||
| 14:00 | Rot-Weiss Essen | - | Bor. Mönchengladbach II | 4:0 (0:0) | ||
| 14:00 | SC Wiedenbrück | - | Preußen Münster | 1:1 (0:1) | ||
| 14:00 | Sportfreunde Lotte | - | Rot-Weiß Oberhausen | 1:0 (0:0) | ||
| 14:00 | VfB Homberg | - | SV 19 Straelen | 1:1 (0:1) | ||
| 14:00 | Wuppertaler SV | - | SV Bergisch Gladbach 09 | 2:0 (0:0) | ||
| 15:30 | 1. FC Köln II | - | FC Schalke 04 II | 5:2 (1:2) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 29 | 20 | 8 | 1 | 73:21 | 52 | 68 |
| 2 |
|
Rot-Weiss Essen | 29 | 19 | 7 | 3 | 61:19 | 42 | 64 |
| 3 |
|
Preußen Münster | 30 | 18 | 6 | 6 | 47:25 | 22 | 60 |
| 4 |
|
Fortuna Düsseldorf II | 29 | 15 | 7 | 7 | 57:30 | 27 | 52 |
| 5 |
|
Fortuna Köln | 30 | 14 | 10 | 6 | 52:35 | 17 | 52 |
| 6 |
|
Rot-Weiß Oberhausen | 30 | 12 | 10 | 8 | 48:37 | 11 | 46 |
| 7 |
|
SV Rödinghausen | 30 | 12 | 9 | 9 | 38:31 | 7 | 45 |
| 8 |
|
1. FC Köln II | 29 | 12 | 8 | 9 | 49:39 | 10 | 44 |
| 9 |
|
Bor. Mönchengladbach II | 30 | 12 | 6 | 12 | 40:42 | -2 | 42 |
| 10 |
|
SV 19 Straelen | 30 | 10 | 9 | 11 | 34:42 | -8 | 39 |
| 11 |
|
SC Wiedenbrück | 29 | 8 | 14 | 7 | 37:37 | 0 | 38 |
| 12 |
|
FC Schalke 04 II | 30 | 9 | 11 | 10 | 35:37 | -2 | 38 |
| 13 |
|
Alemannia Aachen | 30 | 9 | 10 | 11 | 27:33 | -6 | 37 |
| 14 |
|
Wuppertaler SV | 30 | 10 | 5 | 15 | 34:49 | -15 | 35 |
| 15 |
|
FC Wegberg-Beeck | 29 | 7 | 9 | 13 | 27:43 | -16 | 30 |
| 16 |
|
VfB Homberg | 30 | 8 | 6 | 16 | 29:50 | -21 | 30 |
| 17 |
|
Sportfreunde Lotte | 29 | 6 | 10 | 13 | 29:54 | -25 | 28 |
| 18 |
|
SV Lippstadt 08 | 29 | 5 | 11 | 13 | 28:49 | -21 | 26 |
| 19 |
|
SV Bergisch Gladbach 09 | 30 | 6 | 7 | 17 | 27:52 | -25 | 25 |
| 20 |
|
Bonner SC | 29 | 5 | 6 | 18 | 27:53 | -26 | 21 |
| 21 |
|
Rot Weiss Ahlen | 29 | 3 | 11 | 15 | 31:52 | -21 | 20 |
| Aufstieg | |
| Abstieg |
