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| 05.06.2021 | 14:00 | Bonner SC | - | 1. FC Köln II | 1:0 (0:0) | |
| 14:00 | FC Schalke 04 II | - | Preußen Münster | 3:2 (1:1) | ||
| 14:00 | FC Wegberg-Beeck | - | Rot-Weiss Essen | 0:2 (0:2) | ||
| 14:00 | Rot-Weiß Oberhausen | - | Bor. Mönchengladbach II | 2:0 (0:0) | ||
| 14:00 | Sportfreunde Lotte | - | SC Wiedenbrück | 2:2 (1:0) | ||
| 14:00 | SV Bergisch Gladbach 09 | - | Fortuna Düsseldorf II | 5:2 (1:1) | ||
| 14:00 | SV Rödinghausen | - | Fortuna Köln | 4:1 (2:0) | ||
| 14:00 | SV 19 Straelen | - | SV Lippstadt 08 | 3:1 (1:0) | ||
| 14:00 | VfB Homberg | - | Rot Weiss Ahlen | 0:3 (0:1) | ||
| 14:00 | Wuppertaler SV | - | Borussia Dortmund II | 1:2 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 40 | 27 | 12 | 1 | 94:31 | 63 | 93 |
| 2 |
|
Rot-Weiss Essen | 40 | 27 | 9 | 4 | 90:28 | 62 | 90 |
| 3 |
|
Preußen Münster | 40 | 23 | 9 | 8 | 70:39 | 31 | 78 |
| 4 |
|
Fortuna Köln | 40 | 18 | 12 | 10 | 66:48 | 18 | 66 |
| 5 |
|
1. FC Köln II | 40 | 17 | 10 | 13 | 66:55 | 11 | 61 |
| 6 |
|
SV Rödinghausen | 40 | 15 | 14 | 11 | 52:39 | 13 | 59 |
| 7 |
|
Rot-Weiß Oberhausen | 40 | 15 | 14 | 11 | 61:50 | 11 | 59 |
| 8 |
|
FC Schalke 04 II | 40 | 15 | 12 | 13 | 59:56 | 3 | 57 |
| 9 |
|
Fortuna Düsseldorf II | 40 | 15 | 11 | 14 | 67:53 | 14 | 56 |
| 10 |
|
SC Wiedenbrück | 40 | 13 | 17 | 10 | 55:50 | 5 | 56 |
| 11 |
|
Bor. Mönchengladbach II | 40 | 16 | 7 | 17 | 49:55 | -6 | 55 |
| 12 |
|
Wuppertaler SV | 40 | 16 | 6 | 18 | 57:62 | -5 | 54 |
| 13 |
|
SV 19 Straelen | 40 | 12 | 11 | 17 | 45:61 | -16 | 47 |
| 14 |
|
Alemannia Aachen | 40 | 11 | 12 | 17 | 35:48 | -13 | 45 |
| 15 |
|
Sportfreunde Lotte | 40 | 10 | 14 | 16 | 47:72 | -25 | 44 |
| 16 |
|
SV Lippstadt 08 | 40 | 9 | 13 | 18 | 37:63 | -26 | 40 |
| 17 |
|
FC Wegberg-Beeck | 40 | 9 | 12 | 19 | 36:62 | -26 | 39 |
| 18 |
|
Rot Weiss Ahlen | 40 | 8 | 14 | 18 | 50:69 | -19 | 38 |
| 19 |
|
Bonner SC | 40 | 10 | 8 | 22 | 39:66 | -27 | 38 |
| 20 |
|
VfB Homberg | 40 | 9 | 8 | 23 | 40:75 | -35 | 35 |
| 21 |
|
SV Bergisch Gladbach 09 | 40 | 8 | 9 | 23 | 36:69 | -33 | 33 |
| Aufstieg | |
| Abstieg |
