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| 26.10.2010 | 15:00 | FC Brașov | - | Universitatea Cluj | 2:1 (1:0) | |
| 17:30 | FC Timişoara | - | Voinţa Sibiu | 4:3 (1:0, 1:1, 1:1) i.E. | ||
| 20:00 | Dinamo Bucureşti | - | CS Alro Slatina | 3:1 (3:1) | ||
| 27.10.2010 | 15:00 | Gloria Bistrița (old) | - | FC Unirea | 1:0 (0:0) | |
| 17:30 | CFR Cluj | - | FCM Târgu Mureş | 2:0 (1:0) | ||
| 19:45 | FC Steaua Bucureşti | - | Sportul Studenţesc | 3:1 (0:1, 1:1, 1:1) i.E. | ||
| 28.10.2010 | 17:30 | Pandurii Târgu Jiu | - | FC Universitatea Craiova | 0:2 (0:1) | |
| 19:45 | Astra Ploieşti | - | Rapid Bucureşti | 0:2 (0:0, 0:0) n.V. |
