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| 20.11.2010 | 14:30 | Bo'ness United | - | Buckie Thistle | 0:2 (0:1) | |
| 16:00 | Peterhead FC | - | Cowdenbeath FC | 2:0 (1:0) | ||
| 16:00 | Ross County FC | - | Deveronvale FC | 4:1 (2:0) | ||
| 16:00 | East Fife FC | - | Forfar Athletic | 3:1 (2:0) | ||
| 16:00 | The Spartans FC | - | East Stirlingshire FC | 1:2 (0:1) | ||
| 16:00 | Stirling Albion FC | - | Partick Thistle | 1:3 (0:0) | ||
| 16:00 | Cove Rangers | - | Berwick Rangers | 0:3 (0:2) | ||
| 16:00 | Stenhousemuir FC | - | Threave Rovers | 2:2 (0:1) | ||
| 16:00 | Brechin City FC | - | Annan Athletic | 2:2 (1:0) | ||
| 16:00 | Airdrie United FC | - | Beith Juniors FC | 2:2 (0:1) | ||
| 16:00 | Dumbarton FC | - | Greenock Morton FC | 1:2 (1:1) | ||
| 16:00 | Alloa Athletic | - | Raith Rovers | 4:2 (2:1) | ||
| 16:00 | Montrose FC | - | Whitehill Welfare | 3:1 (2:1) | ||
| 16:00 | Ayr United | - | Sunnybank FC | 5:0 (2:0) | ||
| 16:00 | Elgin City | - | Livingston FC | 2:1 (0:0) | ||
| 16:00 | Stranraer FC | - | Girvan FC | 4:2 (2:1) | ||
| Entscheidungsspiele | ||||||
|---|---|---|---|---|---|---|
| 04.01.2011 | 14:00 | Beith Juniors FC | - | Airdrie United FC | 3:4 (0:3) | |
| 20:30 | Annan Athletic | - | Brechin City FC | 2:5 (1:4) | ||
| 12.01.2011 | 20:30 | Threave Rovers | - | Stenhousemuir FC | 1:5 (0:2) | |
