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| 01.03.2022 | 16:00 | FK Novi Pazar | - | FK Radnički 1923 | 0:1 (0:0) | |
| 18:00 | Proleter Novi Sad | - | Spartak Subotica | 0:3 (0:2) | ||
| 02.03.2022 | 16:00 | FK Metalac | - | Radnički Niš | 1:1 (1:1) | |
| 16:00 | TSC Bačka Topola | - | Radnik Surdulica | 0:0 (0:0) | ||
| 18:00 | FK Čukarički | - | FK Napredak | 3:0 (2:0) | ||
| 18:00 | FK Kolubara | - | Vojvodina | 1:0 (1:0) | ||
| 03.03.2022 | 15:00 | FK Voždovac | - | Crvena Zvezda | 0:3 (0:1) | |
| 17:05 | Partizan | - | Mladost Lučani | 2:1 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Partizan | 25 | 22 | 2 | 1 | 63:9 | 54 | 68 |
| 2 |
|
Crvena Zvezda | 25 | 21 | 3 | 1 | 60:14 | 46 | 66 |
| 3 |
|
FK Čukarički | 25 | 13 | 8 | 4 | 44:24 | 20 | 47 |
| 4 |
|
Vojvodina | 25 | 10 | 6 | 9 | 33:32 | 1 | 36 |
| 5 |
|
Radnički Niš | 25 | 7 | 12 | 6 | 29:26 | 3 | 33 |
| 6 |
|
FK Napredak | 25 | 9 | 5 | 11 | 28:31 | -3 | 32 |
| 7 |
|
FK Kolubara | 25 | 10 | 2 | 13 | 27:46 | -19 | 32 |
| 8 |
|
TSC Bačka Topola | 25 | 8 | 7 | 10 | 38:36 | 2 | 31 |
| 9 |
|
FK Voždovac | 25 | 8 | 6 | 11 | 28:31 | -3 | 30 |
| 10 |
|
Mladost Lučani | 25 | 9 | 3 | 13 | 29:35 | -6 | 30 |
| 11 |
|
Spartak Subotica | 25 | 8 | 6 | 11 | 29:40 | -11 | 30 |
| 12 |
|
Radnik Surdulica | 25 | 6 | 11 | 8 | 19:25 | -6 | 29 |
| 13 |
|
Proleter Novi Sad | 25 | 8 | 3 | 14 | 19:41 | -22 | 27 |
| 14 |
|
FK Metalac | 25 | 6 | 5 | 14 | 30:45 | -15 | 23 |
| 15 |
|
FK Radnički 1923 | 25 | 6 | 4 | 15 | 22:44 | -22 | 22 |
| 16 |
|
FK Novi Pazar | 25 | 3 | 9 | 13 | 22:41 | -19 | 18 |
| Playoffs | |
| Relegation |
