 |
 |
|
|
| 01.10.2021 | 17:00 | FC DAC 1904 | - | Zlaté Moravce | 4:2 (2:0) | |
| 02.10.2021 | 18:00 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 (1:0) | |
| 18:00 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 (0:0) | ||
| 18:00 | ŠKF Sereď | - | FK Senica | 2:1 (1:1) | ||
| 03.10.2021 | 15:00 | Slovan Bratislava | - | FK Pohronie | 5:1 (3:1) | |
| 17:00 | AS Trenčín | - | Spartak Trnava | 0:1 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Slovan Bratislava | 10 | 7 | 2 | 1 | 25:8 | 17 | 23 |
| 2 |
|
Spartak Trnava | 10 | 7 | 2 | 1 | 18:4 | 14 | 23 |
| 3 |
|
MFK Ružomberok | 10 | 4 | 5 | 1 | 14:8 | 6 | 17 |
| 4 |
|
MFK Zemplín Michalovce | 10 | 5 | 1 | 4 | 13:12 | 1 | 16 |
| 5 |
|
FC DAC 1904 | 10 | 4 | 3 | 3 | 16:15 | 1 | 15 |
| 6 |
|
AS Trenčín | 10 | 3 | 5 | 2 | 16:12 | 4 | 14 |
| 7 |
|
MŠK Žilina | 10 | 4 | 2 | 4 | 15:12 | 3 | 14 |
| 8 |
|
FK Senica | 10 | 3 | 4 | 3 | 11:15 | -4 | 13 |
| 9 |
|
ŠKF Sereď | 10 | 3 | 2 | 5 | 8:12 | -4 | 11 |
| 10 |
|
Tatran Liptovský Mikuláš | 10 | 2 | 1 | 7 | 14:25 | -11 | 7 |
| 11 |
|
Zlaté Moravce | 10 | 1 | 3 | 6 | 10:22 | -12 | 6 |
| 12 |
|
FK Pohronie | 10 | 1 | 2 | 7 | 8:23 | -15 | 5 |
| Playoffs | |
| Relegation |
