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| 16.04.2022 | 13:00 | 1461 Trabzon FK | - | Bodrumspor | 0:3 (0:1) | |
| 14:00 | Inegölspor | - | Çorum FK | 1:2 (1:0) | ||
| 17.04.2022 | 14:00 | Adıyamanspor | - | Bayburt İl Özel İdare | 1:1 (0:1) | |
| 14:00 | Afjet Afyonspor | - | Sivas Belediyespor | 0:1 (0:0) | ||
| 14:00 | Ankaraspor | - | Vanspor FK | 2:2 (1:2) | ||
| 14:00 | Diyarbekirspor | - | Kahramanmaraşspor | 3:0 (2:0) | ||
| 14:00 | Ergene Velimeşe | - | Serik Belediyespor | 3:2 (0:2) | ||
| 14:00 | Niğde Anadolu FK | - | Sarıyer SK | 2:0 (0:0) | ||
| 14:00 | Sakaryaspor | - | Turgutluspor | 3:0 (0:0) | ||
| 14:00 | Somaspor | - | Etimesgut Belediyespor | 1:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 35 | 23 | 9 | 3 | 72:22 | 50 | 78 |
| 2 |
|
Bodrumspor | 35 | 21 | 7 | 7 | 59:24 | 35 | 70 |
| 3 |
|
1461 Trabzon FK | 35 | 20 | 7 | 8 | 59:31 | 28 | 67 |
| 4 |
|
Sivas Belediyespor | 35 | 18 | 9 | 8 | 63:32 | 31 | 63 |
| 5 |
|
Çorum FK | 35 | 17 | 10 | 8 | 51:32 | 19 | 61 |
| 6 |
|
Vanspor FK | 35 | 16 | 12 | 7 | 48:41 | 7 | 60 |
| 7 |
|
Afjet Afyonspor | 35 | 17 | 8 | 10 | 61:36 | 25 | 59 |
| 8 |
|
Bayburt İl Özel İdare | 35 | 16 | 9 | 10 | 45:35 | 10 | 57 |
| 9 |
|
Somaspor | 35 | 15 | 7 | 13 | 49:46 | 3 | 52 |
| 10 |
|
Inegölspor | 35 | 14 | 7 | 14 | 49:51 | -2 | 49 |
| 11 |
|
Ankaraspor | 35 | 12 | 12 | 11 | 50:40 | 10 | 48 |
| 12 |
|
Etimesgut Belediyespor | 35 | 11 | 11 | 13 | 41:50 | -9 | 44 |
| 13 |
|
Diyarbekirspor | 35 | 12 | 5 | 18 | 33:40 | -7 | 41 |
| 14 |
|
Sarıyer SK | 35 | 10 | 9 | 16 | 43:52 | -9 | 39 |
|
Serik Belediyespor | 35 | 11 | 6 | 18 | 43:52 | -9 | 39 | |
| 16 |
|
Adıyamanspor | 35 | 11 | 3 | 21 | 41:66 | -25 | 36 |
| 17 |
|
Turgutluspor | 35 | 8 | 10 | 17 | 28:56 | -28 | 34 |
| 18 |
|
Ergene Velimeşe | 35 | 9 | 4 | 22 | 35:70 | -35 | 31 |
| 19 |
|
Niğde Anadolu FK | 35 | 6 | 7 | 22 | 37:77 | -40 | 25 |
| 20 |
|
Kahramanmaraşspor | 35 | 4 | 6 | 25 | 22:76 | -54 | 18 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
