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| 07.01.2022 | 18:00 | Trabzonspor | - | Yeni Malatyaspor | 1:0 (1:0) | |
| 08.01.2022 | 11:30 | Gaziantep FK | - | Fatih Karagümrük SK | 3:1 (2:0) | |
| 14:00 | Alanyaspor | - | İstanbul Başakşehir | 1:1 (1:1) | ||
| 14:00 | Kasımpaşa SK | - | Hatayspor | 3:1 (2:0) | ||
| 17:00 | Galatasaray | - | Giresunspor | 0:1 (0:1) | ||
| 09.01.2022 | 11:30 | Konyaspor | - | Sivasspor | 0:1 (0:0) | |
| 14:00 | Göztepe | - | Antalyaspor | 4:0 (1:0) | ||
| 14:00 | Kayserispor | - | Altay Izmir | 1:0 (1:0) | ||
| 17:00 | Çaykur Rizespor | - | Beşiktaş | 2:2 (0:1) | ||
| 10.01.2022 | 18:00 | Fenerbahçe | - | Adana Demirspor | 1:2 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 20 | 15 | 4 | 1 | 37:14 | 23 | 49 |
| 2 |
|
Konyaspor | 20 | 11 | 6 | 3 | 32:16 | 16 | 39 |
| 3 |
|
İstanbul Başakşehir | 20 | 10 | 4 | 6 | 30:20 | 10 | 34 |
| 4 |
|
Adana Demirspor | 20 | 9 | 6 | 5 | 29:23 | 6 | 33 |
| 5 |
|
Fenerbahçe | 20 | 9 | 5 | 6 | 32:25 | 7 | 32 |
| 6 |
|
Hatayspor | 20 | 10 | 2 | 8 | 28:26 | 2 | 32 |
| 7 |
|
Gaziantep FK | 20 | 9 | 4 | 7 | 27:27 | 0 | 31 |
| 8 |
|
Sivasspor | 20 | 7 | 8 | 5 | 27:20 | 7 | 29 |
| 9 |
|
Beşiktaş | 20 | 8 | 5 | 7 | 32:30 | 2 | 29 |
| 10 |
|
Alanyaspor | 20 | 8 | 5 | 7 | 30:32 | -2 | 29 |
| 11 |
|
Kayserispor | 20 | 7 | 6 | 7 | 28:28 | 0 | 27 |
| 12 |
|
Galatasaray | 20 | 7 | 6 | 7 | 24:24 | 0 | 27 |
| 13 |
|
Fatih Karagümrük SK | 20 | 7 | 6 | 7 | 27:30 | -3 | 27 |
| 14 |
|
Giresunspor | 20 | 7 | 4 | 9 | 20:19 | 1 | 25 |
| 15 |
|
Antalyaspor | 20 | 6 | 4 | 10 | 21:31 | -10 | 22 |
| 16 |
|
Göztepe | 20 | 4 | 6 | 10 | 22:28 | -6 | 18 |
| 17 |
|
Kasımpaşa SK | 20 | 4 | 6 | 10 | 22:29 | -7 | 18 |
| 18 |
|
Altay Izmir | 20 | 5 | 3 | 12 | 23:33 | -10 | 18 |
| 19 |
|
Çaykur Rizespor | 20 | 5 | 3 | 12 | 19:36 | -17 | 18 |
| 20 |
|
Yeni Malatyaspor | 20 | 4 | 3 | 13 | 16:35 | -19 | 15 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
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# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
