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| 04.02.2022 | 18:00 | Kayserispor | - | Hatayspor | 4:3 (1:0) | |
| 18:00 | Konyaspor | - | Giresunspor | 1:0 (0:0) | ||
| 05.02.2022 | 11:30 | Gaziantep FK | - | Sivasspor | 5:1 (3:1) | |
| 14:00 | Fatih Karagümrük SK | - | Yeni Malatyaspor | 1:0 (0:0) | ||
| 14:00 | Trabzonspor | - | Kasımpaşa SK | 1:0 (1:0) | ||
| 17:00 | Fenerbahçe | - | İstanbul Başakşehir | 0:1 (0:0) | ||
| 06.02.2022 | 14:00 | Alanyaspor | - | Galatasaray | 1:1 (1:1) | |
| 14:00 | Çaykur Rizespor | - | Adana Demirspor | 1:3 (0:2) | ||
| 17:00 | Beşiktaş | - | Antalyaspor | 0:0 (0:0) | ||
| 17:00 | Göztepe | - | Altay Izmir | 0:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 24 | 17 | 6 | 1 | 42:17 | 25 | 57 |
| 2 |
|
Konyaspor | 24 | 14 | 6 | 4 | 36:18 | 18 | 48 |
| 3 |
|
Adana Demirspor | 24 | 11 | 7 | 6 | 38:26 | 12 | 40 |
| 4 |
|
İstanbul Başakşehir | 24 | 12 | 4 | 8 | 34:24 | 10 | 40 |
| 5 |
|
Alanyaspor | 24 | 11 | 6 | 7 | 42:34 | 8 | 39 |
| 6 |
|
Fenerbahçe | 24 | 10 | 7 | 7 | 36:29 | 7 | 37 |
| 7 |
|
Beşiktaş | 24 | 10 | 7 | 7 | 35:31 | 4 | 37 |
| 8 |
|
Gaziantep FK | 24 | 10 | 6 | 8 | 32:29 | 3 | 36 |
| 9 |
|
Hatayspor | 24 | 11 | 3 | 10 | 35:38 | -3 | 36 |
| 10 |
|
Kayserispor | 24 | 9 | 7 | 8 | 35:35 | 0 | 34 |
| 11 |
|
Fatih Karagümrük SK | 24 | 9 | 6 | 9 | 30:36 | -6 | 33 |
| 12 |
|
Sivasspor | 24 | 7 | 10 | 7 | 31:29 | 2 | 31 |
| 13 |
|
Galatasaray | 24 | 7 | 7 | 10 | 29:34 | -5 | 28 |
| 14 |
|
Kasımpaşa SK | 24 | 7 | 6 | 11 | 30:32 | -2 | 27 |
| 15 |
|
Göztepe | 24 | 7 | 6 | 11 | 28:33 | -5 | 27 |
| 16 |
|
Giresunspor | 24 | 7 | 5 | 12 | 22:26 | -4 | 26 |
| 17 |
|
Antalyaspor | 24 | 6 | 7 | 11 | 23:34 | -11 | 25 |
| 18 |
|
Çaykur Rizespor | 24 | 6 | 4 | 14 | 22:42 | -20 | 22 |
| 19 |
|
Altay Izmir | 24 | 6 | 3 | 15 | 26:38 | -12 | 21 |
| 20 |
|
Yeni Malatyaspor | 24 | 4 | 5 | 15 | 18:39 | -21 | 17 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
