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| 02.04.2022 | 12:30 | Giresunspor | - | Sivasspor | 2:2 (0:2) | |
| 15:00 | Altay Izmir | - | Antalyaspor | 1:2 (0:1) | ||
| 15:00 | Kayserispor | - | Fenerbahçe | 0:4 (0:2) | ||
| 19:30 | Galatasaray | - | Fatih Karagümrük SK | 2:0 (2:0) | ||
| 03.04.2022 | 12:30 | Kasımpaşa SK | - | Gaziantep FK | 2:1 (1:1) | |
| 15:00 | Alanyaspor | - | Çaykur Rizespor | 2:1 (1:0) | ||
| 15:00 | Konyaspor | - | Göztepe | 3:0 (2:0) | ||
| 19:30 | Trabzonspor | - | Beşiktaş | 1:1 (0:0) | ||
| 04.04.2022 | 19:30 | Hatayspor | - | Adana Demirspor | 0:0 (0:0) | |
| 19:30 | İstanbul Başakşehir | - | Yeni Malatyaspor | 1:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 31 | 21 | 8 | 2 | 59:27 | 32 | 71 |
| 2 |
|
Konyaspor | 31 | 17 | 7 | 7 | 51:33 | 18 | 58 |
| 3 |
|
Fenerbahçe | 31 | 16 | 8 | 7 | 54:35 | 19 | 56 |
| 4 |
|
Alanyaspor | 31 | 15 | 7 | 9 | 57:48 | 9 | 52 |
| 5 |
|
İstanbul Başakşehir | 31 | 15 | 5 | 11 | 43:31 | 12 | 50 |
| 6 |
|
Adana Demirspor | 31 | 13 | 10 | 8 | 46:32 | 14 | 49 |
| 7 |
|
Hatayspor | 31 | 14 | 6 | 11 | 48:46 | 2 | 48 |
| 8 |
|
Beşiktaş | 31 | 12 | 11 | 8 | 45:40 | 5 | 47 |
| 9 |
|
Antalyaspor | 31 | 12 | 8 | 11 | 36:37 | -1 | 44 |
| 10 |
|
Fatih Karagümrük SK | 31 | 12 | 7 | 12 | 36:45 | -9 | 43 |
| 11 |
|
Kasımpaşa SK | 31 | 11 | 8 | 12 | 47:44 | 3 | 41 |
| 12 |
|
Sivasspor | 31 | 10 | 11 | 10 | 42:40 | 2 | 41 |
| 13 |
|
Galatasaray | 31 | 11 | 8 | 12 | 42:45 | -3 | 41 |
| 14 |
|
Gaziantep FK | 31 | 11 | 7 | 13 | 41:44 | -3 | 40 |
| 15 |
|
Kayserispor | 31 | 10 | 8 | 13 | 43:52 | -9 | 38 |
| 16 |
|
Giresunspor | 31 | 10 | 6 | 15 | 34:39 | -5 | 36 |
| 17 |
|
Altay Izmir | 31 | 8 | 5 | 18 | 32:45 | -13 | 29 |
| 18 |
|
Göztepe | 31 | 7 | 6 | 18 | 36:53 | -17 | 27 |
| 19 |
|
Çaykur Rizespor | 31 | 7 | 5 | 19 | 30:57 | -27 | 26 |
| 20 |
|
Yeni Malatyaspor | 31 | 5 | 5 | 21 | 23:52 | -29 | 20 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
