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| 29.01.2011 | 14:30 | UWIC Inter Cardiff | - | Bala Town | 4:1 (2:1) | |
| 15:00 | Carmarthen Town | - | GAP Connah's Quay FC | 2:3 (1:1, 2:2) n.V. | ||
| 15:00 | Grange Quins | - | Bridgend Town | 1:0 (0:0) | ||
| 05.02.2011 | 14:30 | Rhos Aelwyd | - | Prestatyn Town | 1:6 (1:2) | |
| 15:00 | Port Talbot Town | - | Caersws FC | 3:0 (3:0) | ||
| 15:00 | Bangor City | - | Haverfordwest County | 5:3 (1:0) | ||
| 15:00 | Cefn Druids | - | Llanelli AFC | 1:4 (1:2) | ||
| 16:10 | Rhyl FC | - | The New Saints | 1:2 (1:1) |
