| 3. Runde | 21.04.2022 | Orlando City | - | Tampa Bay Rowdies | 2:1 | ||||
| 4. Runde | 11.05.2022 | Orlando City | - | Philadelphia Union | 2:1 | ||||
| Achtelfinale | 26.05.2022 | Orlando City | - | Inter Miami CF | 4:2 i.E. |  |
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| Viertelfinale | 30.06.2022 | Orlando City | - | Nashville SC | 6:5 i.E. | ||||
| Halbfinale | 28.07.2022 | Orlando City | - | New York RB | 5:1 | |
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| Finale | 08.09.2022 | Orlando City | - | Sacramento Republic | 3:0 | |
Uruguay