| 2. Runde | 07.04.2022 | Louisville City FC | - | Chattanooga Red Wolves | 1:0 | ||||
| 3. Runde | 21.04.2022 | Louisville City FC | - | St. Louis City SC 2 | 9:8 i.E. |  |
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| 4. Runde | 11.05.2022 | Detroit City FC | - | Louisville City FC | 2:4 i.E. | ||||
| Achtelfinale | 26.05.2022 | Louisville City FC | - | Nashville SC | 1:2 |
USA