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| H | CD Guabirá | - | Club Aurora | 1:0 (0:0) | ||
| R | Club Aurora | - | CD Guabirá | 0:0 (0:0) | ||
| H: 05.05.2018 02:00 | R: 13.05.2018 21:00 | Sieger: CD Guabirá | ||||
| H | Royal Pari | - | Universitario de Sucre | 1:0 (0:0) | ||
| R | Universitario de Sucre | - | Royal Pari | 0:2 (0:1) | ||
| H: 05.05.2018 21:00 | R: 13.05.2018 23:15 | Sieger: Royal Pari | ||||
| H | Sport Boys Warnes | - | Real Potosí | 0:0 (0:0) | ||
| R | Real Potosí | - | Sport Boys Warnes | 1:2 (1:1) | ||
| H: 05.05.2018 23:15 | R: 13.05.2018 21:00 | Sieger: Sport Boys Warnes | ||||
