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| H | Houston Dynamo | - | Santos Laguna | 1:0 (0:0) | ||
| R | Santos Laguna | - | Houston Dynamo | 3:0 (2:0) | ||
| H: 06.03.2013 02:00 | R: 14.03.2013 01:00 | Sieger: Santos Laguna | ||||
| H | Xelaju MC | - | CF Monterrey | 1:3 (0:2) | ||
| R | CF Monterrey | - | Xelaju MC | 1:1 (0:1) | ||
| H: 07.03.2013 02:00 | R: 13.03.2013 01:00 | Sieger: CF Monterrey | ||||
| H | UANL Tigres | - | Seattle Sounders | 1:0 (0:0) | ||
| R | Seattle Sounders | - | UANL Tigres | 3:1 (0:1) | ||
| H: 07.03.2013 04:00 | R: 13.03.2013 03:00 | Sieger: Seattle Sounders | ||||
| H | CS Herediano | - | Los Angeles Galaxy | 0:0 (0:0) | ||
| R | Los Angeles Galaxy | - | CS Herediano | 4:1 (1:0) | ||
| H: 08.03.2013 02:00 | R: 14.03.2013 03:00 | Sieger: Los Angeles Galaxy | ||||
