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| H | UD Melilla | - | CD Alavés | 1:1 | ||
| R | CD Alavés | - | UD Melilla | 1:0 | ||
| H: 21.05.2011 18:00 | R: 29.05.2011 18:00 | Sieger: CD Alavés | ||||
| H | Real Madrid Castilla | - | CD Alcoyano | 0:2 | ||
| R | CD Alcoyano | - | Real Madrid Castilla | 2:2 | ||
| H: 22.05.2011 12:00 | R: 29.05.2011 19:00 | Sieger: CD Alcoyano | ||||
| H | Orihuela CF | - | CD Guadalajara | 0:2 | ||
| R | CD Guadalajara | - | Orihuela CF | 1:1 | ||
| H: 22.05.2011 17:00 | R: 29.05.2011 19:30 | Sieger: CD Guadalajara | ||||
| H | CD Leganés | - | CF Badalona | 2:1 | ||
| R | CF Badalona | - | CD Leganés | 1:0 | ||
| H: 22.05.2011 19:00 | R: 29.05.2011 19:00 | Sieger: CF Badalona | ||||
| H | Real Unión | - | Sevilla Atlético | 2:1 | ||
| R | Sevilla Atlético | - | Real Unión | 3:0 | ||
| H: 22.05.2011 19:00 | R: 28.05.2011 18:00 | Sieger: Sevilla Atlético | ||||
| H | Cádiz CF | - | CD Mirandés | 2:0 | ||
| R | CD Mirandés | - | Cádiz CF | 4:1 | ||
| H: 22.05.2011 19:00 | R: 29.05.2011 19:00 | Sieger: CD Mirandés | ||||
