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| H | Angers SCO | - | Girondins Bordeaux | 1:4 | ||
| R | Girondins Bordeaux | - | Angers SCO | 6:0 | ||
| H: 06.03.1981 | R: 10.03.1981 | Sieger: Girondins Bordeaux | ||||
| H | Tours FC | - | RC Lens | 1:2 | ||
| R | RC Lens | - | Tours FC | 2:1 | ||
| H: 06.03.1981 | R: 10.03.1981 | Sieger: RC Lens | ||||
| H | AEP Bourg-sous-la-Roche | - | AS Angoulême | 0:1 | ||
| R | AS Angoulême | - | AEP Bourg-sous-la-Roche | 1:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: AS Angoulême | ||||
| H | SÉC Bastia | - | AJ Auxerre | 2:1 | ||
| R | AJ Auxerre | - | SÉC Bastia | 1:1 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: SÉC Bastia | ||||
| H | US Maubeuge | - | LB Châteauroux | 1:3 | ||
| R | LB Châteauroux | - | US Maubeuge | 5:2 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: LB Châteauroux | ||||
| H | AS Poissy | - | Havre AC | 0:0 | ||
| R | Havre AC | - | AS Poissy | 1:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: Havre AC | ||||
| H | Lille OSC | - | CS Thonon-les-Bains | 3:1 | ||
| R | CS Thonon-les-Bains | - | Lille OSC | 1:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: Lille OSC | ||||
| H | USM Malakoff | - | FC Martigues | 1:1 | ||
| R | FC Martigues | - | USM Malakoff | 0:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: FC Martigues | ||||
| H | US Orléans | - | FC Metz | 0:0 | ||
| R | FC Metz | - | US Orléans | 2:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: FC Metz | ||||
| H | Louhans-Cuiseaux | - | Montpellier Paillade SC | 1:2 | ||
| R | Montpellier Paillade SC | - | Louhans-Cuiseaux | 3:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: Montpellier Paillade SC | ||||
| H | Nîmes Olympique | - | AS Nancy Lorraine | 2:4 | ||
| R | AS Nancy Lorraine | - | Nîmes Olympique | 1:1 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: AS Nancy Lorraine | ||||
| H | FC Nantes | - | Paris Saint-Germain | 2:0 | ||
| R | Paris Saint-Germain | - | FC Nantes | 5:3 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: FC Nantes | ||||
| H | FC de Valence | - | AS Saint-Étienne | 0:1 | ||
| R | AS Saint-Étienne | - | FC de Valence | 5:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: AS Saint-Étienne | ||||
| H | US Fécamp | - | RC Strasbourg | 0:3 | ||
| R | RC Strasbourg | - | US Fécamp | 4:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: RC Strasbourg | ||||
| H | La Sportive Thionvilloise | - | SO Pont-de-Chéruy | 2:0 | ||
| R | SO Pont-de-Chéruy | - | La Sportive Thionvilloise | 1:3 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: La Sportive Thionvilloise | ||||
| H | FC Sochaux | - | AS Monaco | 2:1 | ||
| R | AS Monaco | - | FC Sochaux | 1:0 | ||
| H: 07.03.1981 | R: 11.03.1981 | Sieger: AS Monaco | ||||
