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| H | FC Metz | - | Montpellier Paillade SC | 2:1 | ||
| R | Montpellier Paillade SC | - | FC Metz | 1:0 | ||
| H: 02.04.1981 | R: 11.04.1981 | Sieger: Montpellier Paillade SC | ||||
| H | SÉC Bastia | - | AS Monaco | 2:0 | ||
| R | AS Monaco | - | SÉC Bastia | 2:1 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: SÉC Bastia | ||||
| H | FC Nantes | - | Girondins Bordeaux | 1:4 | ||
| R | Girondins Bordeaux | - | FC Nantes | 6:4 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: Girondins Bordeaux | ||||
| H | Havre AC | - | RC Lens | 1:0 | ||
| R | RC Lens | - | Havre AC | 2:0 n.V. | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: RC Lens | ||||
| H | LB Châteauroux | - | Lille OSC | 1:0 | ||
| R | Lille OSC | - | LB Châteauroux | 2:0 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: Lille OSC | ||||
| H | La Sportive Thionvilloise | - | FC Martigues | 2:2 | ||
| R | FC Martigues | - | La Sportive Thionvilloise | 3:0 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: FC Martigues | ||||
| H | AS Nancy Lorraine | - | AS Saint-Étienne | 2:1 | ||
| R | AS Saint-Étienne | - | AS Nancy Lorraine | 3:1 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: AS Saint-Étienne | ||||
| H | RC Strasbourg | - | AS Angoulême | 2:0 | ||
| R | AS Angoulême | - | RC Strasbourg | 2:1 | ||
| H: 03.04.1981 | R: 11.04.1981 | Sieger: RC Strasbourg | ||||
