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| H | Panathinaikos | - | Lamia | 1:0 (1:0) | ||
| R | Lamia | - | Panathinaikos | 0:2 (0:1) | ||
| H: 20.04.2022 18:00 | R: 27.04.2022 17:00 | Sieger: Panathinaikos | ||||
| H | PAOK Saloniki | - | Olympiakos Piraeus | 0:0 (0:0) | ||
| R | Olympiakos Piraeus | - | PAOK Saloniki | 1:1 (0:0, 0:0) n.V. | ||
| H: 21.04.2022 18:30 | R: 27.04.2022 19:00 | Sieger: PAOK Saloniki | ||||
