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| 07.01.2018 | 12:00 | RB Linense | - | CD Badajoz | 2:0 (1:0) | |
| 12:00 | Recreativo Huelva | - | FC Cartagena | 2:3 (1:2) | ||
| 12:00 | UD Melilla | - | UD Las Palmas B | 0:1 (0:0) | ||
| 12:00 | Córdoba CF B | - | Extremadura UD | 3:4 (0:0) | ||
| 17:00 | Lorca Deportiva | - | Real Betis B | 3:1 (1:0) | ||
| 17:00 | Écija Balompié | - | Real Murcia | 1:2 (0:1) | ||
| 17:00 | CD El Ejido 2012 | - | FC Jumilla | 5:0 (3:0) | ||
| 17:00 | CF Villanovense | - | San Fernando CD | 0:0 (0:0) | ||
| 17:30 | UCAM Murcia CF | - | Granada CF B | 2:0 (0:0) | ||
| 18:00 | Mérida AD | - | Marbella FC | 2:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Cartagena | 20 | 11 | 6 | 3 | 28:20 | 8 | 39 |
| 2 |
|
Extremadura UD | 20 | 11 | 5 | 4 | 34:17 | 17 | 38 |
| 3 |
|
UCAM Murcia CF | 20 | 10 | 6 | 4 | 22:17 | 5 | 36 |
| 4 |
|
Marbella FC | 20 | 10 | 4 | 6 | 25:18 | 7 | 34 |
| 5 |
|
Real Murcia | 20 | 9 | 6 | 5 | 27:18 | 9 | 33 |
| 6 |
|
CD El Ejido 2012 | 20 | 7 | 8 | 5 | 33:27 | 6 | 29 |
| 7 |
|
RB Linense | 20 | 7 | 7 | 6 | 26:19 | 7 | 28 |
| 8 |
|
Granada CF B | 20 | 7 | 7 | 6 | 18:17 | 1 | 28 |
| 9 |
|
UD Melilla | 20 | 8 | 4 | 8 | 17:13 | 4 | 28 |
| 10 |
|
Mérida AD | 20 | 6 | 8 | 6 | 21:21 | 0 | 26 |
| 11 |
|
CF Villanovense | 20 | 6 | 8 | 6 | 15:19 | -4 | 26 |
| 12 |
|
Écija Balompié | 20 | 6 | 7 | 7 | 22:28 | -6 | 25 |
| 13 |
|
Recreativo Huelva | 20 | 6 | 7 | 7 | 19:19 | 0 | 25 |
| 14 |
|
San Fernando CD | 20 | 6 | 6 | 8 | 25:26 | -1 | 24 |
| 15 |
|
Córdoba CF B | 20 | 5 | 8 | 7 | 27:25 | 2 | 23 |
| 16 |
|
CD Badajoz | 20 | 5 | 8 | 7 | 25:26 | -1 | 23 |
| 17 |
|
FC Jumilla | 20 | 4 | 8 | 8 | 17:27 | -10 | 20 |
| 18 |
|
Real Betis B | 20 | 4 | 7 | 9 | 22:34 | -12 | 19 |
| 19 |
|
UD Las Palmas B | 20 | 4 | 4 | 12 | 22:32 | -10 | 16 |
| 20 |
|
Lorca Deportiva | 20 | 3 | 6 | 11 | 18:40 | -22 | 15 |
| Playoffs | |
| Playoffs | |
| Relegation | |
| Abstieg |
