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| 16.09.2000 | 20:00 | Standard Liège | - | K.S.C. Eendracht Aalst | 7:0 (4:0) | |
| 20:00 | Sporting Lokeren | - | Sint-Truidense VV | 2:1 (0:0) | ||
| 20:00 | Lierse SK | - | Royal Antwerp FC | 4:1 (2:1) | ||
| 20:00 | RAA La Louviére | - | KV Mechelen | 2:2 (0:0) | ||
| 20:00 | Excelsior Mouscron | - | KVC Westerlo | 3:5 (1:3) | ||
| 20:00 | RSC Anderlecht | - | KRC Harelbeke | 4:3 (2:1) | ||
| 20:00 | KAA Gent | - | KSK Beveren | 5:0 (3:0) | ||
| 17.09.2000 | 15:00 | KRC Genk | - | RSC Charleroi | 2:1 (0:1) | |
| 15:00 | Germinal Beerschot | - | Club Brugge KV | 2:3 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Brugge KV | 6 | 6 | 0 | 0 | 21:6 | 15 | 18 |
| 2 |
|
RSC Anderlecht | 6 | 5 | 1 | 0 | 21:7 | 14 | 16 |
| 3 |
|
KAA Gent | 6 | 4 | 1 | 1 | 15:9 | 6 | 13 |
| 4 |
|
KVC Westerlo | 6 | 4 | 1 | 1 | 12:8 | 4 | 13 |
| 5 |
|
Standard Liège | 6 | 4 | 0 | 2 | 18:8 | 10 | 12 |
| 6 |
|
Excelsior Mouscron | 6 | 4 | 0 | 2 | 18:9 | 9 | 12 |
| 7 |
|
Lierse SK | 6 | 4 | 0 | 2 | 11:5 | 6 | 12 |
| 8 |
|
RSC Charleroi | 6 | 4 | 0 | 2 | 13:10 | 3 | 12 |
| 9 |
|
Sporting Lokeren | 6 | 3 | 2 | 1 | 10:8 | 2 | 11 |
| 10 |
|
KRC Genk | 6 | 2 | 2 | 2 | 8:8 | 0 | 8 |
| 11 |
|
Germinal Beerschot | 6 | 2 | 0 | 4 | 8:11 | -3 | 6 |
| 12 |
|
KSK Beveren | 6 | 2 | 0 | 4 | 4:14 | -10 | 6 |
| 13 |
|
KRC Harelbeke | 6 | 1 | 1 | 4 | 11:17 | -6 | 4 |
| 14 |
|
Royal Antwerp FC | 6 | 1 | 0 | 5 | 4:11 | -7 | 3 |
| 15 |
|
RAA La Louviére | 6 | 0 | 3 | 3 | 4:15 | -11 | 3 |
| 16 |
|
Sint-Truidense VV | 6 | 0 | 2 | 4 | 5:11 | -6 | 2 |
| 17 |
|
KV Mechelen | 6 | 0 | 2 | 4 | 6:16 | -10 | 2 |
| 18 |
|
K.S.C. Eendracht Aalst | 6 | 0 | 1 | 5 | 5:21 | -16 | 1 |
