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| 11.04.2022 | 15:00 | RFC Seraing II | - | KV Kortrijk II | 5:1 | |
| 15:00 | Excelsior Virton II | - | RWDM Brussels FC II | 3:2 | ||
| 17:00 | KV Oostende II | - | KAS Eupen II | 2:3 | ||
| 19:30 | Royal Excel Mouscron II | - | K Beerschot VA II | 2:1 | ||
| 19:30 | SK Beveren II | - | KVC Westerlo II | 2:3 | ||
| 20:00 | Lierse Kempenzonen II | - | Lommel SK II | 1:0 | ||
| 20:00 | SK Deinze II | - | Union St. Gilloise II | 0:2 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
K Beerschot VA II | 25 | 18 | 4 | 3 | 65:22 | 43 | 58 |
| 2 |
|
KAS Eupen II | 25 | 18 | 3 | 4 | 61:32 | 29 | 57 |
| 3 |
|
KV Oostende II | 25 | 14 | 7 | 4 | 61:32 | 29 | 49 |
| 4 |
|
Excelsior Virton II | 25 | 13 | 2 | 10 | 57:63 | -6 | 41 |
| 5 |
|
Royal Excel Mouscron II | 25 | 12 | 4 | 9 | 49:31 | 18 | 40 |
| 6 |
|
Union St. Gilloise II | 25 | 11 | 5 | 9 | 36:27 | 9 | 38 |
| 7 |
|
SK Beveren II | 25 | 11 | 2 | 12 | 42:36 | 6 | 35 |
| 8 |
|
RFC Seraing II | 25 | 11 | 2 | 12 | 41:39 | 2 | 35 |
| 9 |
|
RWDM Brussels FC II | 25 | 11 | 2 | 12 | 49:49 | 0 | 35 |
| 10 |
|
KVC Westerlo II | 25 | 9 | 2 | 14 | 38:46 | -8 | 29 |
| 11 |
|
Lierse Kempenzonen II | 25 | 8 | 4 | 13 | 30:58 | -28 | 28 |
| 12 |
|
SK Deinze II | 25 | 6 | 3 | 16 | 25:54 | -29 | 21 |
| 13 |
|
Lommel SK II | 25 | 5 | 4 | 16 | 26:59 | -33 | 19 |
| 14 |
|
KV Kortrijk II | 25 | 3 | 6 | 16 | 32:64 | -32 | 15 |
| Aufstieg |
