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| H | Valledupar FC | - | Atlético FC | 1:1 (1:1) | ||
| R | Atlético FC | - | Valledupar FC | 3:4 (0:0, 0:0, 0:0) i.E. | ||
| H: 09.02.2022 20:00 | R: 23.02.2022 20:00 | Sieger: Valledupar FC | ||||
| H | Real Santander | - | Barranquilla FC | 3:0 (2:0) | ||
| R | Barranquilla FC | - | Real Santander | 0:0 (0:0) | ||
| H: 09.02.2022 20:10 | R: 23.02.2022 22:00 | Sieger: Real Santander | ||||
| H | Boca Juniors de Cali | - | Fortaleza FC | 0:1 (0:0) | ||
| R | Fortaleza FC | - | Boca Juniors de Cali | 1:0 (1:0) | ||
| H: 09.02.2022 21:00 | R: 23.02.2022 23:00 | Sieger: Fortaleza FC | ||||
| H | Tigres FC | - | Leones FC | 2:0 (0:0) | ||
| R | Leones FC | - | Tigres FC | 1:1 (0:0) | ||
| H: 09.02.2022 23:30 | R: 23.02.2022 21:00 | Sieger: Tigres FC | ||||
| H | Orsomarso SC | - | Llaneros FC | 0:0 (0:0) | ||
| R | Llaneros FC | - | Orsomarso SC | 2:0 (0:0) | ||
| H: 10.02.2022 21:00 | R: 23.02.2022 21:00 | Sieger: Llaneros FC | ||||
| H | Deportes Quindío | - | Bogotá FC | 1:0 (0:0) | ||
| R | Bogotá FC | - | Deportes Quindío | 2:2 (1:1) | ||
| H: 11.02.2022 00:00 | R: 24.02.2022 23:30 | Sieger: Deportes Quindío | ||||
| H | Atlético Huila | - | Real Cartagena | 1:0 (0:0) | ||
| R | Real Cartagena | - | Atlético Huila | 0:0 (0:0) | ||
| H: 11.02.2022 02:00 | R: 25.02.2022 02:00 | Sieger: Atlético Huila | ||||
