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| 15.04.2006 | 18:00 | Sporting Gijón | - | CD Tenerife | 2:2 (1:2) | |
| 18:30 | UE Lleida | - | Gimnàstic de Tarragona | 1:2 (0:1) | ||
| 18:30 | Albacete | - | Recreativo Huelva | 1:0 (1:0) | ||
| 18:30 | Elche CF | - | Real Madrid Castilla | 2:1 (0:1) | ||
| 16.04.2006 | 12:00 | Levante UD | - | CD Numancia | 1:0 (0:0) | |
| 17:30 | Racing Ferrol | - | UD Almería | 1:1 (1:0) | ||
| 18:00 | Polideportivo Ejido | - | CD Castellón | 0:2 (0:1) | ||
| 18:00 | SD Eibar | - | Hércules CF | 0:1 (0:1) | ||
| 19:00 | Lorca Deportiva | - | Xerez CD | 1:1 (0:1) | ||
| 19:00 | Real Valladolid | - | Ciudad de Murcia | 0:2 (0:0) | ||
| 20:30 | Real Murcia | - | Atlético Malagueño | 4:1 (3:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Gimnàstic de Tarragona | 33 | 19 | 5 | 9 | 40:29 | 11 | 62 |
| 2 |
|
Recreativo Huelva | 33 | 16 | 11 | 6 | 45:25 | 20 | 59 |
| 3 |
|
UD Almería | 33 | 16 | 7 | 10 | 42:30 | 12 | 55 |
| 4 |
|
Xerez CD | 33 | 14 | 12 | 7 | 49:35 | 14 | 54 |
| 5 |
|
Levante UD | 33 | 14 | 12 | 7 | 42:35 | 7 | 54 |
| 6 |
|
Ciudad de Murcia | 33 | 15 | 9 | 9 | 39:32 | 7 | 54 |
| 7 |
|
Lorca Deportiva | 33 | 15 | 8 | 10 | 45:32 | 13 | 53 |
| 8 |
|
CD Numancia | 33 | 14 | 9 | 10 | 34:37 | -3 | 51 |
| 9 |
|
Real Madrid Castilla | 33 | 13 | 7 | 13 | 42:34 | 8 | 46 |
| 10 |
|
Elche CF | 33 | 12 | 9 | 12 | 42:45 | -3 | 45 |
| 11 |
|
Real Valladolid | 33 | 11 | 11 | 11 | 43:41 | 2 | 44 |
| 12 |
|
Hércules CF | 33 | 11 | 10 | 12 | 33:37 | -4 | 43 |
| 13 |
|
Sporting Gijón | 33 | 9 | 15 | 9 | 31:27 | 4 | 42 |
| 14 |
|
Real Murcia | 33 | 10 | 12 | 11 | 31:29 | 2 | 42 |
| 15 |
|
Albacete | 33 | 11 | 8 | 14 | 33:48 | -15 | 41 |
| 16 |
|
Polideportivo Ejido | 33 | 11 | 7 | 15 | 32:41 | -9 | 40 |
| 17 |
|
UE Lleida | 33 | 10 | 8 | 15 | 35:37 | -2 | 38 |
| 18 |
|
CD Castellón | 33 | 9 | 9 | 15 | 32:40 | -8 | 36 |
| 19 |
|
CD Tenerife | 33 | 9 | 9 | 15 | 40:49 | -9 | 36 |
| 20 |
|
Racing Ferrol | 33 | 7 | 14 | 12 | 37:46 | -9 | 35 |
| 21 |
|
Atlético Malagueño | 33 | 6 | 9 | 18 | 26:47 | -21 | 27 |
| 22 |
|
SD Eibar | 33 | 4 | 13 | 16 | 21:38 | -17 | 25 |
