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| 20.05.2006 | 18:30 | Ciudad de Murcia | - | Racing Ferrol | 2:1 (2:0) | |
| 18:30 | SD Eibar | - | UE Lleida | 1:1 (1:0) | ||
| 19:15 | Hércules CF | - | Elche CF | 0:0 (0:0) | ||
| 19:30 | CD Numancia | - | Albacete | 1:0 (0:0) | ||
| 22:00 | CD Tenerife | - | Polideportivo Ejido | 2:1 (1:0) | ||
| 21.05.2006 | 12:00 | UD Almería | - | Recreativo Huelva | 2:1 (1:0) | |
| 17:30 | Real Madrid Castilla | - | Atlético Malagueño | 4:1 (2:0) | ||
| 18:00 | CD Castellón | - | Gimnàstic de Tarragona | 0:2 (0:2) | ||
| 18:00 | Real Valladolid | - | Lorca Deportiva | 1:1 (0:0) | ||
| 19:00 | Sporting Gijón | - | Levante UD | 0:2 (0:1) | ||
| 19:00 | Xerez CD | - | Real Murcia | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Recreativo Huelva | 38 | 20 | 11 | 7 | 59:28 | 31 | 71 |
| 2 |
|
Gimnàstic de Tarragona | 38 | 22 | 5 | 11 | 46:35 | 11 | 71 |
| 3 |
|
Levante UD | 38 | 18 | 12 | 8 | 49:37 | 12 | 66 |
| 4 |
|
Lorca Deportiva | 38 | 18 | 10 | 10 | 54:37 | 17 | 64 |
| 5 |
|
Ciudad de Murcia | 38 | 18 | 10 | 10 | 48:40 | 8 | 64 |
| 6 |
|
UD Almería | 38 | 18 | 7 | 13 | 47:35 | 12 | 61 |
| 7 |
|
Xerez CD | 38 | 16 | 12 | 10 | 54:41 | 13 | 60 |
| 8 |
|
CD Numancia | 38 | 17 | 9 | 12 | 43:44 | -1 | 60 |
| 9 |
|
Real Madrid Castilla | 38 | 16 | 7 | 15 | 49:40 | 9 | 55 |
| 10 |
|
Real Valladolid | 38 | 13 | 12 | 13 | 50:49 | 1 | 51 |
| 11 |
|
Sporting Gijón | 38 | 11 | 16 | 11 | 37:32 | 5 | 49 |
| 12 |
|
Elche CF | 38 | 13 | 10 | 15 | 45:52 | -7 | 49 |
| 13 |
|
Albacete | 38 | 13 | 10 | 15 | 38:52 | -14 | 49 |
| 14 |
|
Real Murcia | 38 | 12 | 12 | 14 | 36:35 | 1 | 48 |
| 15 |
|
Hércules CF | 38 | 12 | 12 | 14 | 35:42 | -7 | 48 |
| 16 |
|
CD Castellón | 38 | 12 | 10 | 16 | 38:45 | -7 | 46 |
| 17 |
|
Polideportivo Ejido | 38 | 13 | 7 | 18 | 41:49 | -8 | 46 |
| 18 |
|
CD Tenerife | 38 | 12 | 9 | 17 | 47:55 | -8 | 45 |
| 19 |
|
UE Lleida | 38 | 10 | 10 | 18 | 38:47 | -9 | 40 |
| 20 |
|
Racing Ferrol | 38 | 7 | 15 | 16 | 40:55 | -15 | 36 |
| 21 |
|
SD Eibar | 38 | 5 | 15 | 18 | 25:42 | -17 | 30 |
| 22 |
|
Atlético Malagueño | 38 | 6 | 11 | 21 | 30:57 | -27 | 29 |
