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| 05.03.2022 | 13:45 | Niki Volou FC | - | Pierikos Katerini | 2:0 (2:0) | |
| 06.03.2022 | 13:45 | Apollon Lárissa | - | Panserraikos | 1:0 (1:0) | |
| 13:45 | AE Lárissa | - | AEP Iraklis FC | 3:0 (1:0) | ||
| 13:45 | PAOK Saloniki II | - | Apollon Pontou | 2:1 (1:0) | ||
| 13:45 | Olympiakos Volou | - | Anagennisi Karditsa | 0:1 (0:1) | ||
| 13:45 | Almopos Arideas | - | Xanthi FC | 2:2 (1:2) | ||
| 13:45 | AO Kavala | - | Thesprotos | 1:1 (0:1) | ||
| 16:00 | AO Trikala | - | Veria FC | 1:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 21 | 16 | 3 | 2 | 46:17 | 29 | 51 |
| 2 |
|
AE Lárissa | 20 | 13 | 6 | 1 | 29:6 | 23 | 45 |
| 3 |
|
Anagennisi Karditsa | 21 | 11 | 5 | 5 | 31:18 | 13 | 38 |
| 4 |
|
Xanthi FC | 20 | 9 | 8 | 3 | 30:14 | 16 | 35 |
| 5 |
|
PAOK Saloniki II | 21 | 8 | 8 | 5 | 27:20 | 7 | 32 |
| 6 |
|
Niki Volou FC | 21 | 8 | 7 | 6 | 24:14 | 10 | 31 |
| 7 |
|
AEP Iraklis FC | 21 | 6 | 11 | 4 | 22:16 | 6 | 29 |
| 8 |
|
Olympiakos Piraeus II | 20 | 7 | 7 | 6 | 23:21 | 2 | 28 |
| 9 |
|
Almopos Arideas | 21 | 7 | 6 | 8 | 28:24 | 4 | 27 |
| 10 |
|
Thesprotos | 20 | 6 | 6 | 8 | 25:21 | 4 | 24 |
| 11 |
|
Apollon Lárissa | 20 | 5 | 7 | 8 | 15:25 | -10 | 22 |
| 12 |
|
Apollon Pontou | 21 | 5 | 6 | 10 | 23:31 | -8 | 21 |
| 13 |
|
AO Trikala | 21 | 5 | 5 | 11 | 16:31 | -15 | 20 |
| 14 |
|
Pierikos Katerini | 21 | 4 | 7 | 10 | 20:31 | -11 | 19 |
| 15 |
|
AO Kavala | 21 | 4 | 6 | 11 | 16:61 | -45 | 18 |
| 16 |
|
Panserraikos | 21 | 3 | 8 | 10 | 20:31 | -11 | 17 |
| 17 |
|
Olympiakos Volou | 21 | 4 | 4 | 13 | 22:36 | -14 | 16 |
| Playoffs | |
| Abstieg |
|
# Apollon Lárissa wurde mit einem Abzug von 6 Punkten belegt. |
