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| 06.11.2022 | 14:30 | ACD Nardò | - | Martina | 0:0 | |
| 14:30 | Team Altamura | - | Lavello | 3:0 | ||
| 14:30 | SS Barletta Calcio | - | Afragolese | 2:0 | ||
| 14:30 | Cavese | - | US Bitonto | 1:0 | ||
| 14:30 | Gladiator | - | FC Francavilla | 1:1 | ||
| 14:30 | Matera Calcio | - | Brindisi | 2:1 | ||
| 14:30 | Sporting Fulgor Molfetta | - | FBC Gravina | 1:0 | ||
| 14:30 | Puteolana Internapoli | - | ASG Nocerina | 1:1 | ||
| 16:00 | Città di Fasano | - | Casarano | 2:0 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cavese | 10 | 7 | 2 | 1 | 19:7 | 12 | 23 |
| 2 |
|
Città di Fasano | 10 | 6 | 3 | 1 | 18:8 | 10 | 21 |
| 3 |
|
Brindisi | 10 | 5 | 3 | 2 | 18:10 | 8 | 18 |
| 4 |
|
ACD Nardò | 10 | 4 | 6 | 0 | 9:3 | 6 | 18 |
| 5 |
|
SS Barletta Calcio | 10 | 5 | 3 | 2 | 8:6 | 2 | 18 |
| 6 |
|
Casarano | 10 | 4 | 5 | 1 | 17:12 | 5 | 17 |
| 7 |
|
Team Altamura | 10 | 4 | 4 | 2 | 16:11 | 5 | 16 |
| 8 |
|
Afragolese | 10 | 3 | 4 | 3 | 16:14 | 2 | 13 |
| 9 |
|
Gladiator | 10 | 3 | 3 | 4 | 12:14 | -2 | 12 |
| 10 |
|
Martina | 10 | 3 | 3 | 4 | 11:14 | -3 | 12 |
| 11 |
|
ASG Nocerina | 10 | 2 | 5 | 3 | 12:12 | 0 | 11 |
| 12 |
|
Sporting Fulgor Molfetta | 10 | 2 | 4 | 4 | 16:17 | -1 | 10 |
| 13 |
|
FC Francavilla | 10 | 2 | 3 | 5 | 10:14 | -4 | 9 |
| 14 |
|
Matera Calcio | 10 | 2 | 3 | 5 | 12:19 | -7 | 9 |
| 15 |
|
Lavello | 10 | 2 | 3 | 5 | 7:17 | -10 | 9 |
| 16 |
|
US Bitonto | 10 | 2 | 2 | 6 | 8:15 | -7 | 8 |
| 17 |
|
FBC Gravina | 10 | 0 | 7 | 3 | 5:10 | -5 | 7 |
| 18 |
|
Puteolana Internapoli | 10 | 0 | 5 | 5 | 8:19 | -11 | 5 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
