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| 22.01.2023 | 14:30 | Afragolese | - | FC Francavilla | 3:2 (2:1) | |
| 14:30 | ASG Nocerina | - | Martina | 0:1 (0:0) | ||
| 14:30 | SS Barletta Calcio | - | Cavese | 1:1 (1:0) | ||
| 14:30 | Casarano | - | Lavello | 3:0 (1:0) | ||
| 14:30 | Città di Fasano | - | ACD Nardò | 0:0 (0:0) | ||
| 14:30 | Matera Calcio | - | Gladiator | 5:0 (3:0) | ||
| 14:30 | Puteolana Internapoli | - | Sporting Fulgor Molfetta | 4:1 (1:1) | ||
| 15:00 | Team Altamura | - | US Bitonto | 1:2 (1:2) | ||
| 15:00 | Brindisi | - | FBC Gravina | 3:1 (2:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cavese | 20 | 11 | 6 | 3 | 35:21 | 14 | 39 |
| 2 |
|
SS Barletta Calcio | 20 | 10 | 7 | 3 | 22:15 | 7 | 37 |
| 3 |
|
Brindisi | 20 | 10 | 6 | 4 | 34:20 | 14 | 36 |
| 4 |
|
ACD Nardò | 20 | 9 | 9 | 2 | 22:13 | 9 | 36 |
| 5 |
|
Team Altamura | 20 | 9 | 8 | 3 | 30:18 | 12 | 35 |
| 6 |
|
Casarano | 20 | 8 | 10 | 2 | 30:20 | 10 | 34 |
| 7 |
|
Città di Fasano | 20 | 9 | 6 | 5 | 30:19 | 11 | 33 |
| 8 |
|
Matera Calcio | 20 | 8 | 6 | 6 | 34:30 | 4 | 30 |
| 9 |
|
US Bitonto | 20 | 8 | 5 | 7 | 26:24 | 2 | 29 |
| 10 |
|
ASG Nocerina | 20 | 6 | 6 | 8 | 25:28 | -3 | 24 |
| 11 |
|
Martina | 20 | 6 | 6 | 8 | 25:29 | -4 | 24 |
| 12 |
|
Gladiator | 20 | 5 | 7 | 8 | 26:34 | -8 | 22 |
| 13 |
|
Afragolese | 20 | 4 | 9 | 7 | 28:29 | -1 | 21 |
| 14 |
|
FC Francavilla | 20 | 4 | 6 | 10 | 22:28 | -6 | 18 |
| 15 |
|
Sporting Fulgor Molfetta | 20 | 3 | 7 | 10 | 26:35 | -9 | 16 |
| 16 |
|
FBC Gravina | 20 | 2 | 10 | 8 | 14:26 | -12 | 16 |
| 17 |
|
Lavello | 20 | 4 | 4 | 12 | 15:37 | -22 | 16 |
| 18 |
|
Puteolana Internapoli | 20 | 1 | 8 | 11 | 17:35 | -18 | 11 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
