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| 02.10.2022 | 15:00 | Martina | - | Brindisi | 0:2 | |
| 15:00 | US Bitonto | - | SS Barletta Calcio | 0:1 | ||
| 15:00 | Casarano | - | ASG Nocerina | 1:1 | ||
| 15:00 | Cavese | - | Matera Calcio | 4:0 | ||
| 15:00 | FC Francavilla | - | Team Altamura | 1:4 | ||
| 15:00 | Gladiator | - | Puteolana Internapoli | 2:1 | ||
| 15:00 | FBC Gravina | - | Afragolese | 1:1 | ||
| 15:00 | Lavello | - | ACD Nardò | 0:0 | ||
| 15:00 | Sporting Fulgor Molfetta | - | Città di Fasano | 2:3 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cavese | 5 | 4 | 0 | 1 | 10:2 | 8 | 12 |
| 2 |
|
SS Barletta Calcio | 5 | 4 | 0 | 1 | 4:2 | 2 | 12 |
| 3 |
|
Brindisi | 5 | 3 | 2 | 0 | 10:3 | 7 | 11 |
| 4 |
|
Città di Fasano | 5 | 3 | 2 | 0 | 9:4 | 5 | 11 |
| 5 |
|
Casarano | 5 | 3 | 2 | 0 | 9:5 | 4 | 11 |
| 6 |
|
ACD Nardò | 5 | 2 | 3 | 0 | 5:1 | 4 | 9 |
| 7 |
|
Gladiator | 5 | 3 | 0 | 2 | 7:6 | 1 | 9 |
| 8 |
|
Team Altamura | 5 | 2 | 2 | 1 | 9:5 | 4 | 8 |
| 9 |
|
Afragolese | 5 | 2 | 2 | 1 | 9:6 | 3 | 8 |
| 10 |
|
ASG Nocerina | 5 | 1 | 3 | 1 | 4:4 | 0 | 6 |
| 11 |
|
US Bitonto | 5 | 1 | 2 | 2 | 5:8 | -3 | 5 |
| 12 |
|
FBC Gravina | 5 | 0 | 4 | 1 | 4:5 | -1 | 4 |
| 13 |
|
Lavello | 5 | 1 | 1 | 3 | 4:8 | -4 | 4 |
| 14 |
|
Matera Calcio | 5 | 1 | 0 | 4 | 5:11 | -6 | 3 |
| 15 |
|
Martina | 5 | 1 | 0 | 4 | 4:11 | -7 | 3 |
| 16 |
|
Sporting Fulgor Molfetta | 5 | 0 | 2 | 3 | 7:10 | -3 | 2 |
| 17 |
|
Puteolana Internapoli | 5 | 0 | 2 | 3 | 5:12 | -7 | 2 |
| 18 |
|
FC Francavilla | 5 | 0 | 1 | 4 | 3:10 | -7 | 1 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
