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| 23.10.2022 | 15:00 | ACD Nardò | - | FC Francavilla | 2:1 | |
| 15:00 | Afragolese | - | Lavello | 1:1 | ||
| 15:00 | SS Barletta Calcio | - | ASG Nocerina | 1:1 | ||
| 15:00 | Gladiator | - | Cavese | 1:3 | ||
| 15:00 | Matera Calcio | - | Casarano | 2:2 | ||
| 15:00 | Sporting Fulgor Molfetta | - | US Bitonto | 3:1 | ||
| 15:00 | Puteolana Internapoli | - | Martina | 1:3 | ||
| 15:30 | Team Altamura | - | Brindisi | 1:1 | ||
| 16:00 | Città di Fasano | - | FBC Gravina | 3:0 |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Città di Fasano | 8 | 5 | 3 | 0 | 16:6 | 10 | 18 |
| 2 |
|
Cavese | 8 | 5 | 2 | 1 | 16:6 | 10 | 17 |
| 3 |
|
Casarano | 8 | 4 | 4 | 0 | 16:9 | 7 | 16 |
| 4 |
|
Brindisi | 8 | 4 | 3 | 1 | 15:7 | 8 | 15 |
| 5 |
|
ACD Nardò | 8 | 3 | 5 | 0 | 8:3 | 5 | 14 |
| 6 |
|
SS Barletta Calcio | 8 | 4 | 2 | 2 | 5:5 | 0 | 14 |
| 7 |
|
Afragolese | 8 | 3 | 4 | 1 | 15:10 | 5 | 13 |
| 8 |
|
Gladiator | 8 | 3 | 2 | 3 | 11:12 | -1 | 11 |
| 9 |
|
Team Altamura | 8 | 2 | 4 | 2 | 10:9 | 1 | 10 |
| 10 |
|
ASG Nocerina | 8 | 2 | 4 | 2 | 9:8 | 1 | 10 |
| 11 |
|
Martina | 8 | 3 | 1 | 4 | 9:12 | -3 | 10 |
| 12 |
|
US Bitonto | 8 | 2 | 2 | 4 | 8:13 | -5 | 8 |
| 13 |
|
Sporting Fulgor Molfetta | 8 | 1 | 4 | 3 | 14:15 | -1 | 7 |
| 14 |
|
FBC Gravina | 8 | 0 | 6 | 2 | 5:9 | -4 | 6 |
| 15 |
|
Lavello | 8 | 1 | 3 | 4 | 6:14 | -8 | 6 |
| 16 |
|
FC Francavilla | 8 | 1 | 2 | 5 | 7:13 | -6 | 5 |
| 17 |
|
Matera Calcio | 8 | 1 | 2 | 5 | 8:16 | -8 | 5 |
| 18 |
|
Puteolana Internapoli | 8 | 0 | 3 | 5 | 7:18 | -11 | 3 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
